ELM2-SANT Domain-Containing Scaffolding Protein 1 Regulates Differentiation and Maturation of Cardiomyocytes Derived From Human-Induced Pluripotent Stem Cellsdoi:10.1161/JAHA.124.034816Yu-An LuJiacheng SunLu WangMeimei WangYalin WuGetachew, Anteneh
The SANT-domain-containing co-repressors SMRT, NCoR and SMRTER interact with Class IHDACsin complexes that are tethered to DNA by transcription factors such as the Notch pathway component CSL andnuclear receptors[43,50]. In the mouse, SMRT and NCoR maintain multipotent neural progenitors and inh...
Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2 TRF2 is a component of shelterin, the telomere-specific protein complex that prevents DNA damage signaling and inappropriate repair at the natural ends of ......
MSANTD3 encodes a previously uncharacterized Myb/SANT domain-containing protein. Immunohistochemical staining demonstrated diffuse nuclear MSANTD3 expres- sion in 8 of 27 AcCC cases (30%), including the three cases with MSANTD3 rearrange- ment. MSANTD3 displayed heterogen...
1). An NH2-terminal signal sequence containing a putative cleavage site between amino acids 47 and 48 could target the signature J-domain (residues 63–138) to the lumen of the endoplasmic reticulum where it can interact with BiP (22, 23, 24). The J-domain is followed by a membrane ...
SANT domains are found in a number of chromatin regulators. They contain approximately 50 amino acids and have high similarity to the DNA binding domain of Myb related proteins. Though some SANT domains associate with DNA others have been found to bind u
The Terminal acidic SANT 1 (Tacs1) gene of maize is expressed in tissues containing meristems and encodes an acidic SANT domain similar to some chromatin-remodeling complex proteins. | Marian, CO. and Bass, HW. 2005. Biochim Biophys Acta. 1727: 81-6. PMID: 15716051 Evidence for allosteric...
Deletion analysis revealed that this interaction occurs through a region containing the SANT domain of hMI-ER1. Together, these data reveal a functional role for the SANT domain in the action of co-repressor regulatory factors and suggest that the association of hMI-ER1 with Sp1 represents a ...
Sequence alignment revealed that GbRL2 had high homology with other single SANT/MYB domain containing genes, including the RADIALIS genes in Antirrhinum majus and Bournea leiophylla . Semi-quantitative reverse transcript polymerase chain reaction (RT-PCR) revealed that at seedling stage, GbRL2 was ...
To address the question of HAT domain deletions on SAGA composition, we analyzed complexes prepared from two N-terminal truncation mutants, gcn5Δ169N containing residues 170–439 (deleting region I of the Gcn5 HAT domain) or gcn5Δ253Ncontaining residues 254–439 (deleting the entire HAT ...