Drug–drug interaction (DDI) trials are an important part of drug development as they provide evidence on the benefits and risks when two or more drugs are taken concomitantly. Sample size calculation is typically recommended to be based on the existence of clinically justified no‐effect ...
The more participants that take the drug the more the researcher can rely on the information they discover. There are problems with this as it is not always possible to get a very large sample size and in some cases impossible. For example, if researching a very rare disease it is ...
Secondly, there is little value in a post hoc calculation which takes the form of, for example, 'we observed a difference of 14% which was not significant; however, the power of detecting a difference of 14% or greater for our sample size would have been <50%'; it can be shown that...
Hidden populations, such as injection drug users and sex workers, are central to a number of public health problems. However, because of the nature of thes... MJ Salganik - 《Journal of Urban Health》 被引量: 558发表: 2006年 Sample size calculation should be performed for design accuracy ...
Our exact calculation reveals that the actual a was 9.7% and power was 90.4% in the sample-size calculation. The trial had major recruitment problems and it could have been designed with a ¼ 10.4% and power ¼ 88.8% to give a stage 1 sample size of 13 out of 27 and stage II ...
Box plots help you compare several distributions at once, so that you can see the structure in your data, identify problems (if any), and check assumptions required for the ANOVA, such as normal distributions and equal variability. The data set for the one-way ANOVA consists of k ...
The calculation of the margin of error for stratified and clustered designs requires the use of specialized techniques. Making the assumption that these complex designs are like simple random samples, and analyzing them accordingly, is likely to result in the overestimation of the margin of error (...
Power and Sample Size Calculation for Microarray Studies Microarray is a technology to screen a large number of genes to discover those differentially expressed between clinical subtypes or different conditions o... SH Jung,SS Young - 《Journal of Biopharmaceutical Statistics》 被引量: 23发表: 2012...
J. Regulatory problems caused by contamination, a frequently overlooked cause of veterinary drug residues. J. Chromatogr. A. 882, 37–52 (2000). Article CAS Google Scholar Regulation (EC) No 1831/2003 of the European Parliament and of the Council of 22 September 2003 on additives for use ...
The specific calculation formula is as follows: $$\:\text{I}2=\frac{Q-df}{Q}\times\:100\text{\%}$$ (2) Pleiotropy test: MR-Egger method was used to test the pleiotropy of instrumental variables. If the P value of MR-Egger’s intercept is less than 0.05, it indicates that ...