Our data provide a comprehensive analysis of these seemingly identical, yet different, proteins in human cells and provide the molecular basis for establishing these proteins as potential drug target candidates. 2. Materials and methods 2.1. Protein expression and purification Genes encoding human Kti12...
Although several antiviral drugs had been approved for CHB, they caused significant side effects and drug resistance. In contrast, TCM treatment was regarded as a safe and effective method for CHB and Liver fibrosis [8, 9]. TCM treatment is based on the traditional diagnose method to ...
but is required for correct Cav2 channel allocation to the axonal versus the dendritic domain. We suggest that the two different putative α2δ subunits are required in the same neurons to regulate different functions of VGCCs.
Human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells, hold enormous promise for many biomedical applications, such as regenerative medicine, drug testing, and disease modeling. Although induced pluripotent stem cells resemble embryonic stem cells both morphologically...
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13. The nonwoven web according to claim 1 wherein the plurality of inter-entangled, polar solvent-soluble, non-thermoplastic filaments comprise two or more different filament-forming materials. 14. The nonwoven web according to claim 1 wherein the plurality of inter-entangled, polar solvent-solub...
Ubiquitylation is a protein modification implicated in several cellular processes. This process is reversible by the action of deubiquinating enzymes (DUBs). USP45 is a ubiquitin specific protease about which little is known, aside from roles in DNA dama
functional food without limitation. The food composition of the present invention may be prepared in various types of formulations, and unlike general drugs, it has an advantage of having no side effects that may occur when a drug is taken for a long time by using food as a raw material ...
Further, when a hard capsule is used as an inhalation capsule preparation, a single dose of the drug is sealed in the hard capsule, and the capsule is pierced with a small pin to enable inhalation of the drug inside at an appropriate flow rate. In this case, the capsule film does not...
Kruppel-like factor 2 (KLF2) is a positive transcriptional regulator of several endothelial protective molecules, including thrombomodulin (TM), a surface receptor, and endothelial nitric oxide synthase (eNOS), an enzyme that generates nitric oxide (NO).