The global loss of heterochromatin during ageing has been observed in eukaryotes from yeast to humans, and this has been proposed as one of the causes of ageing. However, the cause of this age-associated loss of heterochromatin has remained enigmatic. He
Biochemistry 60, 1506–1519 (2021). Article CAS PubMed Google Scholar Benjdia, A. et al. Thioether bond formation by SPASM domain radical SAM enzymes: Cα H-atom abstraction in subtilosin A biosynthesis. Chem. Commun. 52, 6249–6252 (2016). Article CAS Google Scholar Morinaka, B. I...
Download: Download full-size imagePrevious article in issue Next article in issue Subject areas Pharmacology Biochemistry Stem cells research Cancer Introduction Studies focused on tumor heterogeneity demonstrate continued support for the concept of cancer stem cells (CSCs), harboring self-renewal and tumor...
In addition, Smaug also directly recruits Argonatue 1 (Ago1) to target mRNA and thereby repress unlocalizednanosmRNA translation through binding two SREs in thenanos3’-UTR in a miRNA-independent manner [27]. Ago1 protein is typically recruited to target mRNA by microRNA (miRNA) to form the...
Download: Download full-size image Figure 4. Cryo-EM structures of dGTPase with dGTP bound in the active site. A, H125A dGTPase (gray) bound to both dGTP substrate (teal) and dATP activator (pink) (th 0.11). The postprocessed map was generated using DeepEMhancer, whereas the image was...
Full text Abstract: Sequence files formats (FASTA and FASTQ) are commonly used in bioinformatics, molecular biology and biochemistry. With the advent of next-generation sequencing (NGS) technologies, the number of FASTQ datasets produced and analyzed has grown exponentially, urging the development of...
A learning volume control, acclimation manager, and in-situ loudness balance Voice prompts and low battery warnings Nano coated for moisture resistance Lucid Hearing’s prescription custom in-ear hearing aids feature IIC, ITC, and half-shell and full-shell ITE designs, ranging from 32 to 128 cha...
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BONE MORPHOGENETIC PROTEINS: BIOLOGY, BIOCHEMISTRY AND RECONSTRUCTIVE SURGERY. T. Sam Lindholm. Austin, Texas, R. G. Landes Company and Academic Press, 1996. $69.95, 311 pp.The concept that there is a substance in bone that can induce new-bone formation has been discussed for many years. ...
Neri D, Szyperski T, Otting G, Senn H, Wuthrich K: Stereospecific nuclear magnetic resonance assignments of the methyl groups of valine and leucine in the DNA-binding domain of the 434 repressor by biosynthetically directed fractional 13C labeling. Biochemistry 1989, 28(19):7510–7516. 10.1021...