A salicylate allergy is a misnomer because it does not involve the specific immune reactions seen with a true allergy. Rather, it is considered a form of intolerance.1 With an allergy, exposure to certain substances triggers the release of an antibody calledimmunoglobulin E (IgE). This, in t...
It is used in low concentrations as a flavoring agent (no more than 0.04 %; it is toxic). It is also used to provide fragrance to various products and as an odor-masking agent for some organophosphate pesticides . If used excessively, it can cause stomach and kidney problems. ...
A 56-year-old man had an anaphylactoid reaction to lysine aspirin during a bronchial challenge test; facial flushing and generalized pruritus were followed by shortness of breath, a cold sweat, and wheezing; his blood pressure fell from 130/80 to 70/50 mmHg, and he was drowsy; his FEV1 ...
**p < 0.01, ***p < 0.001 by Student’s t-test. (d) EMT marker expression after low dose treatment for 4 days of the MUC1 expressing clones. A representative sample of 3 independent experiments shown, data displayed is the mean +/− SEM (n = 3). *p < 0.05 ...
Test Type Exposure routes Species Result Assessment : Local lymph node assay (LLNA) : Skin contact : Mouse : positive : Probability or evidence of low to moderate skin sensitisation rate in humans (+)-Bornan-2-one: Test Type Exposure routes Species : Buehler Test : Skin contact : Guinea ...
On this basis, we chose to test all the m-substituted analogs at our disposal, irrespective of their performance on the Mtb ortholog. According to our results, compound 1h proved to be the most effective against Mab-SaS, with an IC50 value in the low micromolar range (Table 1). Therefore...
administered orally, the phosphonate compounds herein are only about 10% absorbed through the gut, the rest being excreted. Accordingly, oral compositions typically contain an excess of the phosphonate material over that which can be effectively used in an injectable form to account for the low ...
Blood was obtained for determination of Hct and plasma SA, and the rat was exsanguinated. A midline sternotomy was performed, and cannulas were placed in the pulmonary artery and left atrium. The lungs were removed and perfused with 0.9% saline at 15 mL/min in a nonrecirculating manner ...
To test this hypothesis, we measured the metabolism of a model drug, para-aminosalicylate (PAS). Volunteers and cancer patients ingested a single oral dose (2 g) of PAS and we measured the plasma disappearance curve of the drug and its metabolite. In 7 patients suffering from lymphosarcoma,...
blood-brain barrier penetration (C. brain/C. blood): >2 high absorption to CNS; between 0.1 and 2 middle absorption to CNS, while <0.1 represents low absorption to CNS. b percent human intestinal absorption: 0–20% poorly absorbed; 20–70% moderately absorbed, while 70–100% is well-abs...