Both the Ventolin and Medihaler-Duo inhalers substantially increased FEV(1), but in the doses used salbutamol was more effective than isoprenaline/phenylephrine (P < 0.01). There was no significant difference between two and six puffs of salbutamol, though there seemed to be an advantage of ...
and about 65% after intravenous administration. Unchanged salbutamol appears to undergo active tubular secretion. Salbutamol is almost exclusively metabolised by conjugation to a 4′-O-sulphate ester in the gastrointestinal tract and liver. The metabolite possesses little or noβ...
The sample size was calculated to detect a difference in the RDAI score between day one and day three. The estimated sample size for a two-sample comparison of proportions of each group that achieved the four-unit difference was with a probability of type one error of 0.05 and type 2 error...
This suggests that weight change is not a good indicator of drug output. Furthermore, there was a marked difference in peak salbutamol output between the two nebulizer units, being 2·9 mg (55%) with the Micro-Neb unit and 1·98 mg (38·7%) with the System 22 unit....
Our primary outcome was the difference in the rate of occurrence of PRAE between children having received salbutamol and those having received placebo prior to surgery. We hypothesized that there would be a significant decrease (≥13%) in the rate of PRAE in children receiving salbutamol compared...
·mL -1,respectively.The relative bioavailability of the generic product was 63%.Two one-sided t-tests and 90% CI (45%～88%) demonstrated that the two salbutamol MDIs were not bioequivalent.Ventolin produced stronger bronchodilating effect than the generic product.ANOVA on the key ...
Relative bioavailability of salbutamol to the lung following inhalation via two versions of a novel dry powder inhaler (Clickhaler) and a standard pressurized metered dose inhaler (Ventolin). Pharm Pharmacol Comm 1995; 4: 107±109.Hindle M, Peers EM, Parry-Billings M, Chrystyn H. Relative ...
RESULTS--The mean (SD) urinary salbutamol excretion 30 minutes after inhalation with the metered dose inhalers used with the Volumatic was 22.22 (4.63) and 21.30 (5.91) micrograms for the Baker Norton and Ventolin respectively, with a mean difference (95% confidence interval (CI)) of 0.92 (...
The objective of this research was to compare the efficacy and tolerability of 10 mg oral bambuterol (Bambec) once daily (in the evening) with 2 mg oral albutamol (Ventolin) administered four times daily in 20 patients. Those were 18 to 60 years old and diagnosed with asthma or COPD, ...
However, adding AS to Ventolin Evohaler has doubled the pulmonary salbutamol bioavailability and almost diminished drug precipitation in the oral cavity. In addition to its recent anti-microbial growth technology and inhalation valve design improvements, AS can provide extra Funding This academically ...