1. Because common pMEIs, especially those with high AF in the genomes of healthy people, can harbor large insertions (300 base pairs (bps)—6000 bps) without apparent deleterious effects, we reasoned that these pMEI sites are plausible candidates for GSH selection (Fig. 1a). From common pME...
Genomic safe harborMobile genetic elementsBackground:Genomic safe harbors are regions of the genome that can maintain transgene expression without disrupting the function of host cells. Genomic safe harbors play an increasingly important role in improving the efficiency and safety of genome engineering. ...
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