using differential scanning fluorimetry (DSF), microscale thermophoresis (MST), and surface plasmon resonance (SPR). ADIPOR2 bound SCM-198 directly in vitro, as revealed by a direct pull-
We identify adiponectin receptor 2 (AdipoR2) as a selective target of SCM-198, with the AdipoR2 R335 residue being critical for the binding and signaling of SCM-198-AdipoR2 and AdipoR2 Y274 residue serving as a molecular switch for Ca2+ influx. SCM-198-AdipoR2 binding causes Ca2+ influx...