During the transition from puberty to adulthood, S100a4-Cre;Ptch1fl/fl mice of both sexes develop hypogonadism coupled with reduced gonadotropin levels. Their pituitary glands also display severe structural and functional abnormalities, as revealed by transmission electron microscopy and expression of ...
目的:利用Cre-LoxP重组酶系统构建成纤维细胞中Ddr2特异性敲除的纯合子小鼠并鉴定,为进一步研究Ddr2在肺纤维化中的作用提供基础.方法:将购买的Ddr2 loxp小鼠和成纤维细胞特异表达的S100a4-Cre小鼠分别繁殖与鉴定,然后将两种小鼠杂交与鉴定,最终得到基因型为Cre^× Ddr2^flox/flox的纯合子小鼠就是在成纤维细胞中Ddr...
S100a4-Cre× Ddr2flox/flox条件敲除小鼠的繁育及基因型鉴定主要由王涛、康涛、雷琦编写,在2018年被《现代生物医学进展》收录,原文总共6页。
We found that the Pik3caH1047R;Trp53R270H;MMTV-Cre double mutant mice had a shorter latency of 36.6 weeks for tumor development compared to 62 weeks in Pik3caH1047R;MMTV-Cre mice. Some of the double mutant animals also developed metastasis. Here, we report S100a4 to be a candidate ...
S100a4 upregulation in Pik3caH1047R;Trp53R270H;MMTV-Cre-driven mammary tumors promotes metastasisH1047RTumor-free survival of double mutant H1047R; R270H; mice. H1047R; mice were crossed with R270Hflox mice to obtain the H1047R; R270H; mice. Kaplan–Meier plot depicting tumor-free survival ...