S-adenosyl-L-homocysteine hydrolase : key regulator of cellular metabolismFakult, NaturwissenschaftlichenUniversit, KarlfranzensMalanovic, Nermina
S-Adenosyl-L-homocysteine hydrolase (EC 3.3.1.1) is an important enzyme in the trans-sulphuration pathway, mediating the conversion of S-adenosyl-L-homocysteine to adenosine and L-homocysteine. We have identified a cDNA clone from Xenopus laevis , encoding a protein of 433 aa, which is highly...
In vivo, the reaction is driven in the direction of homocysteine formation by the action of the enzyme adenosine deaminase which converts the second product of the S-adenosylhomocysteine hydrolase reaction, adenosine, to inosine. Except for methyl transfer from betaine and from methylcobalamin in the...
1. Advances in research of novel drugs based on S-adenosyl-L-homocysteine hydrolase as a potential target; 以S-腺苷同型半胱氨酸水解酶为潜在靶点的新药研究进展2) S-adenosylhomocysteine hydrolase (SAHH) S-腺苷-L-同型半胱氨酸水解酶3) S-adenosylhomocysteine S-腺苷同型半胱氨酸 1. The ...
S-Adenosyl-L-homocysteine (SAH) hydrolase catalyzes breakdown of SAH, which arises after S-adenosylmethionine-dependent methylation, into adenosine and homocysteine. The enzyme activity is required for both metabolic pathway of sulfur-containing amino acids and a variety of biological methylations. Becaus...
6). Fig. 6 A shows that the hydrolase activity in pxSAHHase3.1(−)zeo-transfected HEK293 cells of 1.66 ± 0.27 nm/min/mg (n = 6) is significantly greater than the 0.90 ± 0.16 nm/mg/min (n = 6) observed in control-transfected cells. Moreover, the methylation of AFC, depicted ...
An enzyme captured in two conformational states: crystal structure of S‐adenosyl‐L‐homocysteine hydrolase from Bradyrhizobium elkanii S-Adenosyl-l-homocysteine hydrolase (SAHase) is involved in the enzymatic regulation of S-adenosyl-l-methionine (SAM)-dependent methylation reactions. Afte... T Man...
S-Adenosyl-l-homocysteine hydrolase (SAHH) catalyzes the reversible hydrolysis of S-adenosylhomocysteine (SAH) into Ado and l-homocysteine. SAH is produced as a by-product of S-adenosylmethionine (SAM)-dependent methyltransferase reactions. The importance of methylation in numerous biochemical processes ...
De Clercq E (1998) Carbocyclic adenosine analogues as S- adenosylhomocysteine hydrolase inhibitors and antiviral agents: recent advances. Nucleosides Nucleotides 17:625-634Carbocyclic Adenosine Analogues as S-Adenosylhomocysteine Hydrolase Inhibitors and Antiviral Agents: Recent Advances - Clercq - 1998...
Structure-activity studies on open-chain analogues of nucleosides: Inhibition of S-adenosyl-L-homocysteine hydrolase and antiviral activity 1. Neutral open... Using a rapid, quantitative high pressure liquid chromatographic (HPLC) procedure for the separation of S-adenosyl-L-homocysteine (AdoHcy) and...