Macroautophagy/autophagy is a highly conserved metabolic process that degrades intracellular components and recycles bioenergetic substrates. SQSTM1/p62 (sequestosome 1) is a classical autophagy receptor that participates in selective autophagy to eliminate abnormal intracellular components and recycle ...
Mammalian protein SQSTM1/p62 functions as a selective autophagy receptor that regulates selective clearance of intracellular “trash”, thereby playing a vital role in maintaining cellular homeostasi...
S-Acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy. Mol. Cell 83, 3485–3501.e11 (2023). Article CAS PubMed PubMed Central Google Scholar Chamberlain, L. H., Shipston, M. J. & Gould, G. W. Regulatory effects of protein S-acylation on ...
caspase 3 was additionally activated indicating cumulative elimination of irreversibly damaged 我们建议那在初期阶段脊髓压缩,改进的p62表示被触发的NF千字节活动,指挥细胞反应主要对细胞生存,并且autophagy,而在8个星期绳子压缩以后,另外被激活了表明不可逆地损坏的神经细胞的渐增排除的caspase 3与寂静高度被激活的autoph...