In recent years, antibiotics used against some diseases such as K. pneumoniae and E. coli are no longer effective in at least 50% of treated people (Peleg and Hooper, 2010; Shaikh et al., 2015). Moreover, the last option for gonorrhea medical treatment has failed in at least 10 ...
Among 1500 isolates of Streptococcus pneumoniae collected from outpatients at medical centers in the USA between 1994 and 1995, 23.6% were resistant to penicillin: 14.1% had intermediate resistance (MIC 0.1–1.0 mg/L) and 9.5% were highly resistant (MIC ≥2 mg/L) [54]. Similar rates of ...
We found that wild-type cells did not filament when grown in medium with no added Mg2+(Fig. 2b). PhoQ is stimulated under these growth conditions but, as noted above, the level of stimulation is not as high as the level reached with antimicrobial peptide treatment (Fig. 2a). PhoQ stim...
Infection due to multidrug-resistant Gram-negative bacteria has become a major threat to public health1,2. The worldwide search for a truly novel class of antibiotics that can combat such bacteria and overcome antibiotic resistance has continued for the last 40 years1,2,3,4. Cationic peptides ...
Within the last decades, the number of new antibiotics steadily decreased and only recently two novel antibiotics, the antimicrobial lipopeptides daptomycin and oritavancin, were approved by the FDA for the treatment of severe infections caused by Gram-positive bacteria. The efficacy of daptomycin, ...
Functional Study of the Putative Nucleotidase Encoded by spr1057 Gene in Streptococcus Pneumoniae, a Likely Homolog of Escherichia coli Protein YjjG; Univerzita Karlova, Přírodovědecká Fakulta: Staré Město, Czech Republic, 2010. [Google Scholar] Sato, H.; Feix, J.B. Peptide–membrane ...
[9] Gaibani, Paolo et al. “In vivo evolution of resistant subpopulations of KPC-producing Klebsiella pneumoniae during ceftazidime/avibactam treatment.” The Journal of antimicrobial chemotherapy vol. 73,6 (2018): 1525-1529. doi:10.1093/jac/d...
Antibiotic resistance is increasing at a rate that far exceeds the pace of new development of drugs. Antimicrobial peptides, both synthetic and from natural sources, have raised interest as pathogens become resistant against conventional antibiotics. Indeed, one of the major strengths of this class ...
Companies are exploring multiple technologies to fight pathogens such as Pseudomonas aeruginosa and Klebsiella pneumoniae, and next generation vaccines for Streptococcus pneumonia. GSK continues to evolve its infectious disease pipeline to include new classes of antibiotics to address the rising threat...
Rapid design of bacteriophage cocktails to suppress the burden and virulence of gut-resident carbapenem-resistant Klebsiella pneumoniae –Rotman et al – Cell Host & Microbe Bioinformatics SurvBal: Compositional microbiome balances for survival outcomes –Li et al – Bioinformatics q2-metnet: QIIME2 pac...