Entry into S phase; Initiation; Origins of replication; Replication fork and termination; Chromatin and chromosome assembly; Nuclear structure; Replication and cell cycle coupling; Replication and transcription coordination.LaskeyR.A.FairmanM.P.
We have studied the transcription of the CTP:phosphocholine cytidylyltransferase α (CTα) gene in C3H10T1/2 fibroblasts as a function of the cell cycle. The cells were incubated for 48 h with 0.5% fetal bovine serum. The cells were induced into the G1 phase of the cell cycle by the ...
AO2V4 cells had a 50%–80% increase in the percentage of cells in S phase, whereas GJC, GJR and NNR had percentage increases of 20%–40%. IFN-β treatment of normal astrocytes did not significantly alter their cell cycle profile. These data suggest that IFN-β exerts its ...
Constitutive expression of E2F-1 leads to p21-dependent cell cycle arrest in S phase of the cell cycle Eugene S,Tyner Angela L,Gartel Andrei L.Constitutive expression of E2F-1 leads to p21-dependent cell cycle arrest in S phase of the cell cycle.Once... ES Kandel,A Haegebarth,F Najm...
During mammalian cerebral cortex development, the G1-phase of the cell cycle is known to lengthen, but it has been unclear which neural stem and progenitor cells are affected. In this paper, we develop a novel approach to determine cell-cycle parameters in specific classes of neural stem and...
Investigation of ATR essential functions has been technically challenging, especially given the long half-life (>24 h) of ATR protein27. Nonetheless, somatic cells that reside in the G0 phase of the cell cycle for extended periods, such as peripheral lymphocytes, should provide a suitable genet...
S-phase duration is the main target of cell cycle regulation in neural progenitors of developing ferret neocortex. J Comp Neurol. 2016; 524:456-70.Turrero Garcia, M., Chang, Y., Arai, Y. and Huttner, W. B. (2016). S-phase duration is the main target of cell cycle regulation in ...
whereas progression through the later cell cycle phase appears to be regulated primarily by post-transcriptional mechanisms Cell cycle progression through G1 and into S phase is in part regulated by activation of gene transcription, whereas progression through the later cell cycle phase appears to be...
DNA damage activates this pathway, leading to monoubiquitination of the downstream FANCD2 protein and targeting to nuclear foci containing BRCA1. In the current study, we demonstrate that FANCD2 also undergoes monoubiquitination during S phase of the cell cycle. Monoubiquitinated FANCD2 colocalizes ...
Cell cycle, the ordered sequence of events that occur in a cell in preparation for cell division. The cell cycle is a four-stage process in which the cell increases in size, copies its DNA, prepares to divide, and divides. Learn more about the cell cycle