Keywords: immune targets; cancer antigens; neoantigens; cancer vaccines; immunotherapy; innate immune signaling Cell Research (2017) 27:11-37. doi:10.1038/cr.2016.155; published online 27 December 2016 Introduction Cancer immunotherapy is designed to boost or engi- neer immune cells (in particular ...
Phosphomevalonate kinase (PMK) was highly expressed in leaf and fruit, diphosphomevalonate decarboxylase (MVD) was found to be equally expressed in stem, leaf and fruit, while mevalonate kinase (MVK) was highly expressed in rhizome. The FPPS was highly expressed in leaf, while GPPS showed ...
Reducing kidney uptake of radiolabelled exendin-4 using variants of the renally cleavable linker MVK Article Open access 04 September 2023 Introduction Excretion of radiolabelled hydrophilic peptides and small proteins occurs largely via the kidneys. In peptide-receptor radionuclide therapy (PRRT), rapi...
The asymmetric catalytic aza-Morita-Baylis-Hillman (aza-MBH) reaction of isatin-derived ketimines with MVK has been established by using chiral amino and phosphino catalysts. The reaction resulted in biomedically important 3-substituted 3-amino-2-oxindoles in good yields (>80% for most cases) ...
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To do so, when building MoltenVK, set the build setting MVK_USE_METAL_PRIVATE_API=1. This build setting can be set in the MoltenVK.xcodeproj Xcode project, or it can be included in any of the make command-line build commands mentioned above....
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Woerner SM, Gebert J, Yuan YP, Sutter C, Ridder R, Bork P, Doeberitz MVK . 2001 Int. J. Cancer 93: 12–19 Yamamoto H, Sawai H, Perucho M . 1997 Cancer Res. 57: 4420–4426 Zhang L, Yu J, Willson JKV, Markowitz SD, Kinzler KW, Vogelstein B . 2001 Cancer Res. 61: 3801–...
Esteban Mauricio Cordero1, Nobuko Yoshida1, José Franco da Silveira1, Renato Arruda Mortara1 & Diana Bahia1,5 Mevalonate kinase (MVK) is an essential enzyme acting in early steps of sterol isoprenoids biosynthesis, such as cholesterol in humans or ergosterol in trypanosomatid...