sulfuration, sulfonation, S‐alkylationThe palladium-catalyzed reaction of sulfinic acid salts with a wide variety of aryl and vinyl halides or triflates provides unsymmetrical diaryl sulfones and aryl vinyl sulfones in good to excellent yields. The reaction is strongly influenced by the presence of...
chemical as well as materials science, a directmeta-selective C–H functionalization of pyridines is of paramount importance, but such reactions remain limited and highly challenging. In general, established methods formetaC–H functionalization of pyridines rely on the utilization of tailored electrophil...
The use of polar, aprotic solvents, which can solubilize sulfinic acid salts is mandatory for a successful reaction. However, typical polar aprotic solvents, such as DMF or DMSO, led to additional side reactions, presumably by decomposition of the solvent with Tf2O and/or the triflated ...
However, compared with the activated analogs such as sulfonates, ester, and ethers, the remarkable activation barrier of C–OH scission (C–O bond dissociation energy 85–91 kcal mol-116) and polarizability of O–H bond posed great challenge in their utility in allylic alkylation reactions....
Low molecular weight (LMW) thiols are important in numerous processes, where they participate in different types of essential redox reactions (Glossary box), alkylation reactions, and metal binding. Some common biologically relevant LMW thiols include the amino acids cysteine (Cys) and homocysteine,...
to achieve arylation, alkylation, halogenation, borylation or amidation reactions61–65. But the S-sulfonylation or SS-sulfonylation of NHPI esters has not been achieved yet. Recently, Liu reported a copper-catalyzed enantioconvergent C(sp3)-S cross-coupling using racemic secondary and tertiary alkyl...
alkylation, see theSupplementary Informationfor details) without loss ofe.r. andE/Zvalue. The ester unit of9acould undergo a transesterification or aminolysis to afford different kinds of ester-containing styrenes (11a–11c), or amide-containing styrenes (12) in high yields without erosion of ...
(II, X=OH) can be prepared starting from 3-nitro-4-chlorobenzoic acid by nucleophilic introduction of a radical R(1) according to the invention in position 4 (replacement by Cl) and further modification of the nitro group, such as reduction to NH2 and subsequent alkylation or displacement, ...
The main methods employed involve alkylation of salts of sulfinic acids, acidcatalysed condensation of sulfonic acids with aromatic hydrocarbons, and oxidation of diaryl and alkyl aryl sulfides. Oxidation by peracids, N-oxides (catalysed by tetra-n-propylammonium perruthenate), periodate (catalysed by...
Compounds and their pharmaceutically acceptable salts suitable for treating central nervous system disorders associated with the dopamine D3 receptor activity of Formula I: wherein R1 and R2 are independently H, C1-8 alkyl or C1-8 alkylAryl; X is CH2 R3 or NHSO2 R4 ; Y is hydrogen, CH2 R3...