Boergesen, M., et al., Genome-wide profiling of LXR, RXR and PPARalpha in mouse liver reveals extensive sharing of binding sites. Mol Cell Biol, 2011.Boergesen M, Pedersen TA, Gross B, van Heeringen SJ, Hagenbeek D, Bindesbøll C, et al. Genome-wide profilin...
We previously demonstrated that heterodimers of the Peroxisome Proliferator Activated Receptor alpha (PPAR alpha) and the Retinoid X Receptor alpha (RXR alpha) stimulate malic enzyme gene transcription through a regulatory element in the promoter region (ME-PPRE). In this report, we show that the ...
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DNA binding preferences of PPAR alpha/RXR alpha heterodimers. The regulatory elements mediating the transcriptional effects of the Peroxisome Proliferator Activated Receptor (PPAR)/Retinoid X Receptor heterodimers con... H Castelein,PE Declercq,M Baes - 《Biochem Biophys Res Commun》 被引量: 107发表...
此方法中使在生产牲畜产品的农业生产或水产养殖中使用的牲畜动物摄取至少一种含有所述PPAR/RXR异二聚体活化剂和/或其前体的产品(该前体由牲畜动物代谢形成所述PPAR/RXR异二聚体活化剂),历经这样一段时间和以这样的量,使PPAR/RXR异二聚体活化剂累积于牲畜动物体中,而使所述牲畜产品中达到所述增加的PPAR/RXR异...
2型糖尿病ADIPOQ基因PPARγ基因RXRα基因Logistic回归分析目的:探讨江苏汉族人群脂联素通路基因多态性和环境的联合作用与2型糖尿病的关系.方法:采用病例对照研究,收集新... 赵旭,成金罗,高燕勤,... - 《江苏预防医学》 被引量: 0发表: 2011年 PPARgamma/RXRalpha heterodimers control human trophoblast invasion. ...
Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha. Nature 1995, 375, 377–382. [Google Scholar] [CrossRef] McKenna, N.J.; O’Malley, B.W. Combinatorial control of gene expression by nuclear receptors and coregulators. Cell 2002, 108, 465–474. [...
Activation of PPARβ/δ/RXR is also important for neuronal differentiation of neural progenitor cells [57]. However, how classical RAR/RXR signaling pathways are connected to cell responses mediated by such RXR heterodimers in neuronal differentiation is largely unknown, as well as subtype-specific ...
We conclude that (1) in cells expressing high levels of both RXRs and PPARα, such as hepatocytes and kidney cells, these factors are constitutively active; (2) activators of PPARα may increase its ability to form heterodimers with RXRs when the latter are limiting; and (3) hepatoma ...
Peroxisome proliferator-activated receptor (PPAR)-γ is a key transcription activator controlling adipogenesis and lipid metabolism. PPARγ binds PPAR response elements (PPREs) as the obligate heterodimer with retinoid X receptor (RXR) α, but exactly ho