因此,本发明方法特征为该PPAR/RXR异二聚体活化剂为植烷酸、植烷酸代谢物、植烷酸或所述代谢物的衍生物、或它们的组合,以使PPAR/RXR异二聚体活化剂累积在牲畜动物体中,给予该牲畜动物预确定量的该产品至少3天的一段时间,在此过程中该牲畜动物摄食F kg饲料干重的总量,该预确定量的产品包含至少5×F meq,优选至...
4-羟基维甲酸通过与核受体RAR(维甲酸受体)结合调节基因表达和细胞分化,激活RAR和RXR-alpha,诱导癌症细胞凋亡。此外,4-羟基视黄酸还参与免疫调节、神经保护和抗氧化等多种生理过程[1][2]。 CAS号:66592-72-1 分子式:C20H28O3 分子量:316.43 类别:RAR/RXR 密度:1.075g/cm3 沸点:506.5ºC at 760 ...
We previously demonstrated that heterodimers of the Peroxisome Proliferator Activated Receptor alpha (PPAR alpha) and the Retinoid X Receptor alpha (RXR alpha) stimulate malic enzyme gene transcription through a regulatory element in the promoter region (ME-PPRE). In this report, we show that the ...
In the present study, when the binding sites of RXRα-PPARα and FXRα–RXRα in the HBV core promoter were mutated, the inhibitory effect of ZNF148 on the transcription of HBV was abolished. Furthermore, the inhibitory effect of ZNF148 on HBV transcription and replication was lessened by ...
Peroxisome proliferator-activated receptor (PPAR)-γ is a key transcription activator controlling adipogenesis and lipid metabolism. PPARγ binds PPAR response elements (PPREs) as the obligate heterodimer with retinoid X receptor (RXR) α, but exactly ho
Here, we report that hotspot S427F/Y mutations in RXRA or focal amplification/overexpression of PPARG in bladder cancer induce the activation of the PPARγ/RXRα pathway, leading to suppression of cytokine secretion from cancer cells. Non-inflamed immune phenotypes are observed in human bladder tum...
Bexarotene selectively binds and activates retinoid X receptor subtypes (RXR(alpha), RXR(beta), RXR(gamma)). RXRs can form heterodimers with various receptor partners such as retinoic acid receptors (RARs), vitamin D receptor, thyroid receptor, and peroxisome proliferator activator receptors (PPARs...
Peroxisome proliferator-activated receptor-alpha (PPARalpha) is responsible for the hypolipidemic, peroxisome proliferation and carcinogenic effects of fibrates. Rats and mice are responsive, but guinea pigs and primates are resistant to the proliferative and carcinogenic effects of these drugs, but the ...
Disruption of the peroxisomal acyl-CoA oxidase 1 (Acox1) gene in the mouse results in the development of severe microvesicular hepatic steatosis and sustained activation of peroxisome proliferator-activated receptor-α (PPARα). These mice manifest spont
Functional significance of the two ACOX1 isoforms and their crosstalks with PPAR alpha and RXR alpha (90, pg 696, 2010). Lab Investig. 2010;90(5):808-808.Functional significance of the two ACOX1 isoforms and their crosstalks with PPARα and RXRα. Aurore Vluggens,Pierre Andreoletti,Navin...