提出一种广谱性小分子抑制剂 RMC-7977,作为一种可逆的三复合物 RAS 抑制剂,对多种携带 RAS(NRAS、HRAS 和 KRAS)突变的 RAS 成瘾性肿瘤具有明显的抑制效用,临床前数据显示 RMC-7977 治疗导致多种类型的肿瘤消退,且具有良好的耐受...
RAS蛋白作为酪氨酸激酶的下游信号通路蛋白,可被鸟嘌呤核苷酸交换因子(Guanine nucleotide exchange factors, GEFs)如SOS1蛋白调控,而GTP酶激活蛋白(GTPase activating proteins, GAPs)可负向调控RAS蛋白。RAS-GDP为非激活状态,RAS-GTP为激活...
Tan, PBO, Kim, SK (1999) Signaling specificity: the RTK/RAS/MAP kinase pathway in metazoans. Trends Genet 15: pp. 145-149Tan PB, Kim SK: Signaling specificity: The RTK/RAS/MAP kinase pathway in metazoans. Trends Genet 1999, 15: 145–149....
Prostate cancer lineage plasticity is a key driver in the transition to neuroendocrine prostate cancer (NEPC), and the RTK/RAS signaling pathway is a well-established cancer pathway. Nevertheless, the comprehensive link between the RTK/RAS signaling pathway and lineage plasticity has received limited ...
DDR1在某些非恶性肿瘤细胞中起着抑制增殖与生长的作用,如原代鼠系膜细胞,但是尚未有文献报道DDR1能抑制恶性肿瘤细胞的增殖与生长。研究表明,在人乳腺癌和结肠癌中,DDR1主要是通过激活Ras/Raf/ERK和PI3K/Akt通路,从而上调抗凋亡蛋白Bcl-xL和使得细胞在基因毒性应激状态下存活下来 [5, 16-17]。
Advances in molecular mechanisms and targeted therapy of gastric cancer associated with the RTK/RAS signaling pathway 引用 收藏 分享 摘要 目的了解RTK/RAS信号通路相关胃癌的分子机制及靶向治疗研究进展,以期为部分胃癌患者的治疗提供借鉴。方法对近年来国内外关于RTK/RAS信号通路相关胃癌的分子机制及靶向治疗研究的...
The pathway starts with the activation of Ras, a small G protein anchored to the plasma membrane. In its inactive state, Ras is bound to GDP. However, when SH2-containing proteins join with activated RTKs, they cause Ras to bind GTP in place of GDP and become active. Next, the GTP-...
Tan PB, Kim SK (1999) Signaling specificity: the RTK/RAS/MAP kinase pathway in metazoans. Trends Genet 15:145–149Tan, P.B., Kim, S.K.: Signaling specificity: the RTK/RAS/MAP kinase pathway in metazoans. Trends Genet. 15 (... PBO Tan,SK Kim 被引量: 172发表: 1999年 Selective re...
Studies in C. elegans have provided much insight into the basic framework of this RTK/Ras/MAPK signaling pathway, its regulation, how it elicits cell-type specific responses, and how it interacts with other signaling pathways such as the Wnt and Notch pathways. 展开 ...
3 细胞生物学RTK