中国疾控中心健康传播中心公布信息显示,HRSV为肺炎病毒科,正肺病毒属的RNA病毒。HRSV感染后,潜伏期通常为2-8天,临床表现以呼吸道感染症状为主,早期HRSV感染大部分局限于上呼吸道,临床表现如鼻塞、流涕、咳嗽和声音嘶哑等。HRSV感染患儿大多数症状会在1-2周内自行消失,少部分可以发展为下呼吸道感染,主要表现为毛细...
RSV604 did not inhibit viral RNA synthesis in the RSV subgenomic replicon cells or in the cell-free RNP assay, suggesting that it might act prior to viral replication complex formation. RSV604 did not alter N protein localization in the infected cells[2]. Alias (S)-1-(2-Fluorophenyl)-3-...
In contrast, Moderna'svaccineutilizes cutting-edge messenger RNA (mRNA) technology, instructing the body to produce a unique protein that stimulates an immune response, teaching it to defend against the infection. The approval was based on positive trial data published in theNew England Journal of ...
CAMBRIDGE, MA / ACCESSWIRE / January 30, 2023 / Moderna, Inc.(NASDAQ:MRNA), a biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines, today announced mRNA-1345, an investigational mRNA vaccine candidate...
Many human pathogenic viruses (e.g., influenza, coronaviruses, Ebola, HIV, and the respiratory syncytial virus—RSV) are enveloped, meaning they have an outer lipid bilayer derived from the host cell. Therefore, fusion of viral and cellular membranes is a key step in the entry of all envelo...
研究者分别比较了因RSV感染、人类鼻病毒或者流感病毒感染(鼻病毒和流感病毒是LRTI的两个另外的病毒起因)入院治疗的2岁以下儿童和健康的对照儿童的全血RNA转录谱。利用“统计组比较”,他们鉴定了超过2000个转录本,这些转录本在来自45个RSV感染儿童和其他14个健康对照者的血液中出现了差异表达。在RSV感染的儿童中,干扰素...
Human RSV or Respiratory Syncytial Virus is a large RNA virus, member of the family of Pneumoviridae, genus Orthopneumovirus together with bovine RSV virus. Human RSV is responsible for a spectrum of respiratory tract diseases in people of all ages throughout the world. It is the major cause...
RSV products (viral RNA or virus intermediate RNA; vRNA or iRNA, respectively) may enter the endosomes of pDC (which contain TLR) via the process of autophagy; then, viral nucleic acids activate TLR7, thus recruiting MyD88, which causes phosphorylation of IRF7 [35]. IRF7 that is not ...
RSV products (viral RNA or virus intermediate RNA; vRNA or iRNA, respectively) may enter the endosomes of pDC (which contain TLR) via the process of autophagy; then, viral nucleic acids activate TLR7, thus recruiting MyD88, which causes phosphorylation of IRF7 [35]. IRF7 that is not ...