The pathogenesis of severe RSV in older adults is not well characterized, but likely contributing factors include: 2, 3, 4, 5 Underlying cardiopulmonary disease Frailty Weakened immunity In patients with immunocompromise, disease severity may be affected by: 5 Duration and degree of immunosuppressi...
Of the 62 million common colds requiring medical attention in the United States each year, more than 80% affect school-aged children. Controlled clinical trials have demonstrated the effectiveness of zinc gluconate glycine lozenges (Cold-Eeze) in reducing cold duration. The objective of this study ...
Respiratory syncytial virus (RSV) is an important cause of children’s pulmonary infections. However, there are fewer studies on RSV infections in adults. The purpose of this study was to describe the clinical manifestations, para-clinical characteristic
High-risk infants have maternal immunity when born to mothers who were recently infected, but the duration of maternal protection is reduced by 50% compared to low-risk infants [20]. High-risk infants also have a 3 times higher risk of hospitalisation in the first year of life than low-ris...
19、a result of RSV in adults.The annual cost to the NHS of looking after adult patients with RSV is estimated to be around 140m(in 2023 price terms).On top of this is an annual cost to the UKs economy of an estimated 179m due to time off work.Thus,the total economic cost is est...
The symptoms in most infants are similar to those of a bad cold. These include fever, prominent runny nose, cough, and nasal congestion. The duration of these symptoms is 1-2 weeks. During their first RSV infection, some babies and young children also have signs and symptoms of bronchiolitis...
RSV infection can cause severe disease in infants and young children, but with repeated expo- sure and after young childhood, healthy older children and adults present with mostly mild, cold-like symptoms [3, 5–7]. Nearly all children experience an RSV infec- tion by the age of 2 years ...
In adults, it has been shown that resident memory CTL (Trm) proliferate extensively to RSV infection compared to the circulating T cells [198]. Interestingly, this study showed that the Trm were phenotypically lacking cytotoxic markers and had reduced production of pro-inflammatory cytokines but ...
"This is a really key question. People originally anticipated it might have to be an every year immunization. But then we found the duration of protection actually lasts for more than one season, clearly," he said.
GSK also reported that the duration and severity of these events were consistent across both groups. Commenting on the results in a press release, Dr Len Friedland, Vice President of Scientific Affairs and Public Health, GSK, highlighted the importance of adult immunisation, saying: “Adult ...