能与RSV G蛋白的保守表位结合并且在给予人类对象时免疫原性很小的各种单克隆抗体和片段,可用于治疗RSV感染. When conserved epitope capable of binding with RSV G protein and immunogenic in human subjects administered a small variety of monoclonal antibodies and fragments, useful in the treatment of RSV ...
病毒表面的融合蛋白(fusion protein , F)和粘附蛋白(attachment protein, G)因在病毒入侵过程中的关键作用成为病毒研究的理想靶点,而其中G蛋白变异较多相对不稳定,F蛋白也存在Pre到Post构象转变影响其稳定性。 F蛋白是RSV进入宿主细胞时所需的关键跨膜蛋白,它含有多个表位,其中最重要的是A、B和D三个表位。抗体可...
Immobilized prefusion F protein at 0.2 μg/mL (100 μL/well) can bind to a quaternary-dependent epitope specific RSV Pre-F antibody 融合前后构象均识别抗体(识别位点II)验证数据 Immobilized prefusion F protein at 0.015 μg/mL (100 μL/well) and post-F protein can bind to an RSV-specific ...
纯化方式: Protein G 浓度: It differs from different batches. Please contact us to confirm it. 保存缓冲液: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 产品提供形式: Liquid 应用范围: ELISA, WB Protocols: ELISA Protocol Western Blotting (WB) Protocol 储存条件...
人类呼吸道合胞病毒,又称呼吸道融合病毒,简称HRSV(Human Respiratory Syncytial Virus),其名称来源于感染细胞融合时形成的大型细胞,即所谓的合胞体,根据病毒外膜表面的G protein多糖蛋白不同分为A,B两型。 HRSV病毒常爆发于晚春和秋季,有时夏季亦可见,病毒潜伏期(Latent period)约2至8天,病毒脱落期(Shedding period...
et al. Preclinical evaluation of bacterially produced RSV-G protein vaccine: Strong protection against RSV challenge in cotton rat model. Sci Rep 7, 42428 (2017). doi.org/10.1038/srep424 4. Zhu Q, McLellan JS, Kallewaard NL, et al. Highly potent extended half-life antibody as a ...
呼吸道合胞病毒RSV 人类呼吸道合胞病毒(Human Respiratory Syncytial Virus, HRSV)为肺炎病毒科,正肺病毒属的RNA病毒,其基因组全长约15.2kb,编码11个蛋白质。其中 黏附蛋白 (Glycoproteins Protein,G)、融合…
Anti-RSV F protein [MEDI-493] binds with F/Fusion glycoprotein F0 Anti-RSV F Recombinant Antibody (clone MEDI8897) binds with F/Fusion glycoprotein F0 Anti-HRSV F/Fusion glycoprotein F0 Antibody(Am14) binds with glycoprotein F0 RSV疫苗的研发已经有数十年,辉瑞、葛兰素史克和莫德纳近年在研发疫苗取...
其中融合蛋白(fusion protein , F)和粘附蛋白(attachment protein, G)是两个主要的包膜糖蛋白,F为典型的I型糖蛋白,经细胞蛋白酶裂解为F1 和F2 后具有生物学活性,能使病毒包膜与宿主细胞膜融合形成多核巨细胞,G蛋白为II型糖蛋白,能与宿主细胞膜受体结...
ELISA assay validated: Immobilized RSV Pre-fusion protein can bind to a site Ø specific Pre-F antibody 高稳定性 RSV Pre-F蛋白 (Cat: 11049-VNAS) 经反复冻融5次或置于4℃放置48 h后，理化性质不发生改变，稳定性高。ELISA结合实验验证，经过5次反复冻融后的Pre-F蛋白与抗体的结合活性没有降低。Im...