rs1801131是一种基因多态性，也称为MTHFR C677T。AA表示该基因的两个等位基因都是A，即该个体在该位点上的基因型为AA。这意味着该个体在MTHFR基因的C677T位点上没有突变，其编码的酶的活性与正常相同。MTHFR基因编码的酶参与体内同型半胱氨酸代谢，影响体内甲基化反应和DNA合成等生物过程。MTHFR C677...
4. 叶酸的主要表现类型如下: 位点 基因 基因型 类型 rs1801133 C677T MTHFR CC 正常 TT 风险 TC 正常 rs1801131 A1298C MTHFR AA 正常 CC 风险 AC 正常 rs1801394 A66G MTRR GG 风险 AA 正常 AG 风险发布于 2024-09-13 16:00・IP 属地上海 ...
与MTHFR基因rs1801131位点AA基因型比较,AC+CC基因型FA水平降低,Hcy水平增加(P<0.05).携带AC+CC基因型,高Hcy水平,低FA水平可增加URSA易感性(OR=1.437,95%C I:1.234～1.673,P=0.012;OR=1.257,95%C I:1.112～1.421,P=0.035;OR=1.175,95%C I:1.620～2.920,P<0.001).结论 MTHFR基因rs1801131等位基因C和基因...
"rs1801133"和"rs1801131"是两个常见的基因位点，与人类基因组中的多态性相关。这两个位点分别是ACE（血管紧张素转换酶）基因的多态性位点。对于这两个位点的检查，常见的方法是进行基因分型或基因检测。通过分析个体在这些位点上的基因型，可以了解到个体的基因变异情况。正常情况下，这两个位点的基因型...
(CC基因携带);贫血、血小板减少、消化道不良反应的发生率在上述两组患者中无显著性差异;24h、48h的MTX血药浓度中,野生型(CC)患者显著性低于突变杂合子患者(CT)和突变纯合子患者(TT);(2)rs1801131基因多态性:突变型组(AC+AA基因携带)患者出现消化道不良反应、黏膜炎的风险显著性高于野生型组(AA基因携带),而...
Negandhi AA, Hyde A, Dicks E, Pollett W, Younghusband BH, Parfrey P et al. MTHFR Glu429Ala and ERCC5 His46His polymorphisms are associated with prognosis in colorectal cancer patients: analysis of Two independent cohorts from Newfoundland. PLoS One 2013; 8: e61469. Article CAS PubMed Pub...
AA 28(93.3%) 2(6.7%) 0.908 AG 33(91.7%) 3(8.3%) GG 26(89.7%) 3(10.3%) RS1801131T>G TT 16(100.0%) 0(0.0%) 0.502 TG 36(90.0%) 4(10.0%) GG 35(89.7%) 4(10.3%) Overall ADR No significant association between the overall ADR with SNP polymorphism, as illustrated by Tabl...
目的探讨亚甲基四氢叶酸还原酶(MTHFR)基因rs1801131多态性与青海汉族妊娠期高血压疾病(HDCP)的相关性.方法应用限制性片段长度多态性聚合酶链反应(PCR-RFLP),对120例HDCP孕产妇(HDCP组)和120例正常妊娠妇女(对照组)的MTHFR rs1801131进行多态性检测并测序验证.结果HDCP组MTHFR基因AA,AC,CC基因型频率分别为56.67%,...
Subgroup by race showed that the homozygote genotype CC of MTHFR rs1801131 polymorphism was significantly associated with decreased risk of liver cancer in Asians (CC versus AA: OR=0.64, 95% CI 0.46–0.90, P =0.010; for CC versus AA+ AC: OR=0.63, 95% CI 0.45–0.88, P =0.007). ...
包括根据MTHFR基因A1298C rs1801131SNP位点多态性设计的引物和探针,序列如下:MTHFR基因A1298C正向扩增引物:GGAGCTGCTGAAGATGTGG;MTHFR基因A1298C反向扩增引物:CCTCTCGGGAGAACCAAAC;MTHFR基因1298A探针:5'TGAAGAAAGTGTCT3';MTHFR基因1298C探针:5'TGAAGCAAGTGTCT3';操作简单,可推广性强,结果准确,兼容性好,污染风险...