本申请的目的是公开一种检测MTHFR基因A1298C rs1801131SNP位点的试剂盒,其特征在于,包括根据MTHFR基因A1298C rs1801131SNP位点多态性设计的引物和探针,序列如下:MTHFR基因A1298C正向扩增引物:GGAGCTGCTGAAGATGTGG;MTHFR基因A1298C反向扩增引物:CCTCTCGGGAGAACCAAAC;MTHFR基因1298A探针:5'TGAAGAAAGTGTCT3';MTHFR基因...
4. 叶酸的主要表现类型如下: 位点 基因 基因型 类型 rs1801133 C677T MTHFR CC 正常 TT 风险 TC 正常 rs1801131 A1298C MTHFR AA 正常 CC 风险 AC 正常 rs1801394 A66G MTRR GG 风险 AA 正常 AG 风险发布于 2024-09-13 16:00・IP 属地上海 ...
亚甲基四氢叶酸还原酶单核苷酸多态位点MTHFRC677Trs1801133、MTRRA1298Crs1801131、酸甲硫氨酸合成酶还原酶MTRRA66Grs1801394单独或协同作用时,与叶酸代谢能力相关。检测这些位点能揭示受检者在遗传方面叶酸代谢能力的高低,进而给予具有个性化的膳食建议,使得受检者维持在良好的健康水平。 上述方法和试剂盒有助于评估叶...
et al. MTHFR-1298 A>C (rs1801131) is a predictor of survival in two cohorts of stage II/III colorectal cancer patients treated with adjuvant fluoropyrimidine chemotherapy with or without oxaliplatin. Pharmacogenomics J 15, 219–225 (2015). https://doi.org/10.1038/tpj.2014.64 Download citation ...
examined the impact of the C677T and A1298C polymorphisms within the MTHFR gene on the toxicity of MTX in a cohort of patients diagnosed with rheumatoid arthritis (RA). Regarding the MTHFR A1298C polymorphism, it was reported that there was no significant association between the MTHFR A1298C...
MTHFR rs1801131 (A1298C) polymorphism can decrease in vitro MTHFR enzyme activity and has been hypothesized to be associated with liver cancer risk. This study aimed to quantify the strength of the association between MTHFR rs1801131 polymorphism and liver cancer risk by performing a meta-analysis...
阿尔茨海默病亚甲基四氢叶酸还原酶(NADPH)多态性,单核苷酸叶酸高半胱氨酸脑脊髓液淀粉样β肽类认知障碍[摘要] 目的探讨亚甲基四氢叶酸还原酶(MTHFR)基因A1298C(rs1801131)位点多态性与阿尔茨海默病(Alzheimer'sdisease,AD)患者脑脊液β-淀粉样蛋白1-42亚型(Aβ1-42)水平,认知水平及脑结构变化的关系.方法...
Methylenetetrahydrofolate reductase(MTHFR) plays a crucial role in regulating folate metabolism, which affects both DNA synthesis/repair and methylation.Methods: We evaluated the role of MTHFR rs1801133 (C677T) and rs1801131(A1298C) polymorphisms in a case-control study comprised of 462 lung ...
Statistically significant hyperhomocysteinemia was observed in carriers of T allele for MTHFR 677C/T (rs1801133) genotype in young CAD group but this association was not significant for MTHFR 1298A/C (rs1801131) polymorphism. The association between hyperhomocysteinemia and CAD in young group was ...
Therefore, the study of the MTHFR gene A1298C (rs 1801131), C677T (rs 1801133) polymorphisms in the Uzbek population and the significance of the C (rs 1801131) and T (rs 1801133) minor alleles of this gene in the pathogenesis of COVID-19 and in patients with h...