近年来研究发 现,褪黑素受体 1B(melatonin receptor 1B,MTNR1B)基因rs10830963位点多态性与胰岛素抵抗、空腹血糖升高和 2 型糖尿病的发病有关。 但是,MTNR1B 基因多态性与 GDM 的遗传易感性研究未检索到相关报道。本研究对中国 ...
Genome-wide association studies (GWAS) in White Europeans have shown that genetic variation rs10830963 in melatonin receptor 1B gene (MTNR1B) is associated with fasting glucose and type 2 diabetes, which has also been replicated in several Asian populations. As a variant in the gene involved ...
Variants rs10830963 (C/G) and rs1387153 (C/T) in MTNR1B have been shown with an increased risk of developing type 2 diabetes and gestational diabetes mellitus. However, the results are still controversial, and evidence was not satisfied. Hence, a case–control study and a further meta-ana...