The MK-7 homologues of vitamin K2 are characterized by the best bioavailability among other K vitamins and act effectively in the treatment of osteoporosis and cardiovascular diseases. In this article comprehensive structural studies of two intermediates 1,4-diethoxy-2-methylnaphtalene (M2) and 1,4...
The dose of (p < 0.001), route of administration (p < 0.001), and baseline INR (p < 0.001) influenced subsequent INR values. The INR reduction was similar for intravenous doses 2 mg or greater. Home dose did not affect INR responses to intravenous (p = 0.27) or oral (p = 0.98)....
Vitamin K in oral drops and intramuscular injection given at birth to Thai infants were compared to determine whether these routes and doses would influence prothrombin complex activity, mortality or morbidity at 0.5, 1 and 2 months of age. The infants were 321 normal fullterm babies born at ...
Antivitamin B12 Inhibition of the Human B12‐Processing Enzyme CblC: Crystal Structure of an Inactive Ternary Complex with Glutathione as the Cosubstrate B 12 antivitamins are important and robust tools for investigating the biological roles of vitamin B 12 . Here, the potential antivitaminB 12 ...
Cellular uptake of vitamin B 12 in humans is mediated by the endocytosis of the B 12 carrier protein transcobalamin (TC) via its cognate cell surface receptor TCblR, encoded by the CD320gene. Because CD320 expression is associated with the cell cycle and upregulated in highly proliferating ce...
ChemInform Abstract: VITAMIN SYNTHESES WITH CARBENE COMPLEXES. PART 5. A CARBENE COMPLEX ROUTE TO VITAMIN EvitaminsNo abstract is available for this article.doi:10.1002/chin.198405333DOETZ K. H.KUHN W.WILEY‐VCH Verlag GmbHChemischer Informationsdienst...
Takeshi NakaiDep. Chem. Technol., Tokyo Inst. Technol., Meguro, Tokyo 152, JapanJohn Wiley & Sons, Ltd.ChemInformMikoshiba H,Mikami K,Nakai T. A new synthetic route to (S)-chroman aldehyde, a key chiral precursor of vitamin E[J].SYNLETT,2001,(zk):989.doi:10.1055/s-2001-14642....
The progressive and irreversible degeneration of retinal ganglion cells (RGCs) and their axons is the major characteristic of glaucoma, a leading cause of irreversible blindness worldwide. Nicotinamide adenine dinucleotide (NAD) is a cofactor and metabol
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The trafficking of labeled F. tularensis subsp. novicida was compared with the control organisms E. coli and K. pneumoniae using both microPET analysis and radionuclide biodistribution analyses. Our results indicate that F. tularensis subsp. novicida has a differential tissue tropism depending on the...