After validating CSF clearance into the lymph nodes of the neck in swine, a pilot study was conducted in human volunteers to evaluate the effect of gravity on the flow of lymph through these deep cervical lymphatics. Injected into the palatine tonsils, ICG was imaged draining into deep jugular...
Lastly, through endpoint analysis of cellular distribution of exosomes in the node, we identified macrophages and B-cells as key players in exosome uptake. Together these results suggest that exosome transfer by lymphatic flow from the periphery to the lymph node could provide a mechanism for rapid...
Kissenpfennig A, Henri S, Dubois B, Laplace-Builhe C, Perrin P, Romani N et al (2005) Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity 22:643–654 PubMedCASGoogle Scholar Gaiser MR, ...
well as various xenobiotic-metabolizing enzymes exist in the olfactory perineural space as a defense mechanism from foreign substances. The main role of the olfactory/nasal lymphatic route is to maintain the water balance in the brain and export antigens to the cervical lymph nodes via the CSF (...
(https://doi.org/10.1084/jem.20180344) demonstrate that, once secreted by freshly activated plasmablasts, IgM leaves the lymph node via the microarchitecture of the fibroblastic reticular cell conduit. This work demonstrates how the very peculiar stromal compartment of lymphatic organs optimizes the ...
(1996) Human immunodeficiency virus type 1 infection alters chemokine β peptide expression in human monocytes: Implications for recruitment of leukocytes into the brain and lymph nodes. Proc. Natl. Acad. Sci. U.S.A. 63: 700–704. Article Google Scholar Rubin LL, Hall DE, Proter S, Barbu...
A critical step in our delivery system for Toc-siRNA is to undergo “in vivoincubation” with the lymph in the lymphatic vessel, where endogenous chylomicrons are excreted at a high level. This mechanism permits more efficient binding of Toc-siRNA to chylomicrons to form a complex as anin ...
Hepatocellular carcinoma (HCC) invariably exhibits inadequate O2 (hypoxia) and nutrient supply. Hypoxia-inducible factor (HIF) mediates cascades of molecular events that enable cancer cells to adapt and propagate. Macropinocytosis is an endocytic process
One route is by passage of the drug through the portal vein and the liver to flow into the systemic circulation, whereby it is distributed among various parts of the body. The other route is by absorption into the lymph vessels in... H Isamu,Muranishi Shozo,- Kansantachibana-cho,... -...
In particular, there is debate surrounding the route of CSF drainage. Our aim was to quantify CSF flow, volume, and drainage route dynamics in vivo in young and aged spontaneously hypertensive rats (SHR) using a novel contrast-enhanced computed tomography (CT) method. Methods ICP was recorded ...