1.2.4Sublingual route of drug delivery Sublingual routeof drug administration refers drug administration under the tongue. Drugs with desired physio-chemical properties rapidly absorbed through the sublingual mucosa up to 10 folds grater then oral route. The sublingual route shows rapid absorption but pr...
Whatever the explanation, this route of ad- ministration must not be recommended for this drug. In contrast, a standard dose of 5 i.u. of oxytocin administered into the muscle (gluteus, neck) stimulated uterine activity. Consequently, it can be concluded that only the intramuscular route is...
Nasal administration of metoclopramide from different dosage forms: in vitro, ex vivo, and in vivo evaluation. Nasal drug delivery is an interesting route of administration for metoclopramide hydrochloride (MTC) in preventing different kind of emesis. Currently, the... C Tas,CK Ozkan,A Savaser,....
The pharmacokinetics of intranasal and intramuscular cobalamin administration in elderly, cobalamin-deficient patients differ significantly. However, the estimated 2% bioavailability of cobalamin after intranasal administration makes intranasal cobalamin administration a potentially interesting administration route for ...
Food and Drug Administration has approved the first blood test screening option, allowing people to check for colon cancer in a similar way doctors assess their cholesterol and blood sugar.</p> <p>The test, called Shield, uses blood drawn by a medical professional and sent to...
[0054] “Rate of inhalable aerosol particle formation” refers to the number of particles of size between 100 nm and 5 microns produced by an inhalation device per unit time. [0055] “Rate of drug aerosol formation” refers to the mass of aerosolized alprazolam, estazolam, midazolam or triaz...
[0021] Typically, where the aerosol comprises trifluoperazine, the aerosol has an inhalable aerosol drug mass density of between 0.2 mg/L and 10 mg/L. Preferably, the aerosol has an inhalable aerosol drug mass density of between 0.5 mg/L and 8 mg/L. More preferably, the aerosol has an...
Journal of Medical Toxicology December 2007, Volume 3, Issue 4, pp 152-156 Antiemetic use in acetaminophen poisoning: How does the route of N-acetylcysteine administration affect utilization? Melissa A. Miller, Marisela Navarro, Steven B. Bird, Jennifer L. Donovan Download PDF (143 KB)...
Rosa Maria Hernandez, in Nanobiomaterials in Drug Delivery, 2016 11.4.4 Intranasal Administration The intranasal route is an easy and noninvasive way to overcome the BBB’s inherent limitations, enabling the rapid delivery of GFs to the CNS, avoiding the first-pass metabolism. Following intranasal ...
Points above VEH indicate the mean number of trials completed on the spiradoline-appropriate lever in test sessions that followed the administration of drug vehicle (i.e., saline or dis- tilled water). The upper and lower horizontal dashed lines indicate the minimum levels at which ...