(i) for hydrophilic drug molecules which cannot pass through the cell membranes easily, paracellular transport across the BBB is highly restricted and only possible for the small size particles, as tight junctions do not allow the passage through the gap between adjacent endothelial cells, and (ii...
The railway played an important part in the Northwest Rebellion of 1885. It allowed soldiers to get from Ontario and Quebec to the Prairies in only ten days. The railway was also to thank for the discovery of natural gas in Alberta. In 1886, gas was found when construction crews were digg...
Nevertheless, quantitative PCR (qPCR) analyses demonstrated that levels of a set of indicator miRNAs remained relatively steady across samples (Fig. 1c). The proportion of tags mapping to the nuclear genome outside annotated miRNA loci increased from B20% in 2°MEFs to as high as B42% in ...
The intranasal delivery is a part of transmucosal delivery as therapeutic agents need to diffuse across nasal mucosa in olfactory region of nasal cavity which has direct access to brain areas. In such cases, nanoformulations are of prime importance as these can have faster diffusion across nasal ...
while Illinois is home to the world’s largest catsup (ketchup) bottle, stuck atop a water tower in Collinsville. There are also two of the ‘Muffler Men’ — huge fibreglass statues of square-jawed men that were erected across the country in the 1960s to promote everything from motels ...
Mission Santa Barbara: Known as the “Queen of the Missions,” Mission Santa Barbara is a beautiful historic site with lush gardens and a fascinating museum. The rose garden across the street is a perfect spot for a picnic. State Street: This vibrant street is the heart of downtown Santa ...
Mostly across the good old USA, but one stop each in Canada and Mexico.Ahhh, what a great concept for a TV series in this post-war period. Two virile young dudes getting into a gorgeous Corvette and driving aimlessly until the gas money ran out. This was one of the more well written...
Engineering geology considerations for realignment of Interstate 70/76 across the landslide at New Baltimore, Somerset County, SW Pennsylvania . The Pennsylvania Turnpike Commission plans to widen I-76 due to increased traffic in the Somerset County. The New Baltimore landslide, which has caused seriou...
Let’s have a ride on the historic USA highway - Road 66 and cross even 9 states of America! Hook up the trailer, start your big trucks engine and begin the longest ride across the United States of America. Get over explosive obstacles, alien invasion, military forces, alien spaceship ...
Very seldom do I come across a blog that is both informative and entertaining, and let me tell you, youve hit the nail on the head. Your idea is important; the issue is something that not a lot of people are talking intelligently about. I am really happy that I stumbled across this ...