To determine whether the Rosa26 knock-in construct provided functional levels of dCas9-VPR expression, we next investigated parallel transduction of CRISPRa mice with AAV8-Creand a set of five AAV8s containinggRNAstargeting the fiveSerpina1paralogues a-e (AAV8-gSerpina1a, AAV8-gSerpina1b, AAV8...