METHODS For this study platelet‐rich plasma platelet concentrates (PRP‐PCs) were either treated with ROS‐reducing agents (1 mM N‐acetyl‐L‐cysteine [NAC] or 30 μM NADPH oxidase [NOX] inhibitor, VAS2870) or kept untreated during storage. P‐selectin expression, phosphatidylserine (PS) ...
In addi- tion, the relationship between JP8-induced ROS and autophagy was also studied using the ROS scavenger N-acetyl-L-cysteine (NAC) and siRNA knockdown of ATG5, an autophagy gene. Finally, in vivo antitumor activ- ity was examined, and the results showed that JP8 is a promising ...
. Notably, supplement with a ROS scavenger N-acetyl-L-cysteine (NAC) remarkably reduced LDHA nuclear translocation in HPV16/18 E7-transduced cells (Fig.1c, d, and Supplementary Fig.2b, c). This observation triggered us to speculate that ROS possibly promote LDHA nuclear translocation. To this...
英文别名：Acenterine、Acetard、Acetophen、Acetylsalicylic Acid、Acidum Acetylsalicylicum、Adiro、Albyl、Aluprin、Asadrine、Aspirinetas、Bayaspirina、Bi-Prin、Codral Junior、Ecotri、Ecotrin、Elsprin、Empirin、Enteretas、Novosprin、Rhonal、Salitison、Salicylic Acid Acetate拉丁名:Aspirin 化学名称为...
活性氧(ROS)抑制剂/清除剂采用广谱活性氧抑制剂N-乙酰基-L-半胱氨酸(N-acetyl-L-cysteine/LNAC/NAC)抑制/清除细胞样本的各种来源的活性氧。 N-acetyl-L-cysteine 是一种抗氧化剂,在绝大多数细胞样本中,可以有效的清除过氧化氢,羟基自由基和次氯酸等各种类型的活性氧。
The presence of N-acetyl-l-cysteine (NAC), a ROS scavenger, led to further clustering of glycogen in cells by reducing autophagy and enhancing glycophagy, which promoted CPX-induced inhibition of cervical cancer cell proliferation. Together, our study provides new insights into the molecular ...
We found that combinatorial treatment of TBM with ROS scavenger N-Acetyl-cysteine (NAC) resulted in AMPK inhibition, reduced LC3-II turnover and accumulation of GFP-LC3 punta, decreased expression of Beclin1 and Atg5 (Fig. 4e and f). Collectively, these results suggest that activation of ROS...
Acetylcysteine (N-Acetyl-L-cysteine), ROS inhibitor (N-Acetylcysteine,616-91-1) 是一种粘液溶解剂 (mucolytic agent),可用于减少粘液的厚度。Acetylcysteine 是一种 ros抑制剂。Acetylcysteine 是半胱氨酸前体,通过中和花生四烯酸依赖的 5-脂氧合酶活性所产生的毒性脂质来防止血红素诱导的铁中毒 (ferroptosis)。
‘-Cl on mitochondria and apoptosis were substantially blocked in the presence of a combination between z-VAD-FMK and either of the ROS scavenger N-acetyl-L-cysteine (NAC) or pyrrolidine dithiocarbamate (PDTC).Conclusion:We demonstrated that the growth inhibitory effects of 5'-Cl in HL-60 ...
The ROS scavenger N-acetyl L-cysteine (NAC) was used to confirm the role of ROS in escin-induced cell death. NAC decreased ROS levels (Figure 4d). Less autophagic vacuoles and chromatin condensation were observed in cells pretreated with NAC than the p38/MAPK inhibitor (Figure 5a). More...