The invention provides modulators for the orphan nuclear receptor RORγ and methods for treating RORγ mediated chronic inflammatory and autoimmune diseases by administrating these novel RORγ modulators to a human or a mammal in need thereof.
Furthermore, mice with T cell–specific deficiency of Pla2g12a failed to develop disease in an experimental autoimmune encephalomyelitis model of multiple sclerosis. Thus, our data indicate that 1-oleoyl-lysophosphatidylethanolamine is a lipid metabolite that promotes RORγt-induced ...
In the United States alone, cancer causes the death of well over a half-million people annually, with some 1.4 million new cases diagnosed per year. While deaths from heart disease have been declining significantly, those resulting from cancer generally are on the rise. Receptor tyrosine kinases...
These results position ( R )-D4 as a promising and orally bioavailable candidate for Th17-mediated autoimmune disease treatment. Download: Download high-res image (142KB) Download: Download full-size image Download: Download high-res image (142KB) Download: Download full-size image...
For example, helper T cells (Th17), which are associated with inflammatory and autoimmune disease pathogenesis, produce high interleukin (IL)-17 levels [10]. IL-17 has a dominant role in the inflammatory network and is associated with periodontitis traits, suggesting that abnormal, IL-17-induced...
Abstract We identified three retinoid-related orphan receptor gamma t (RORγt)-specific inhibitors that suppress T helper 17 (Th17) cell responses, including Th17-cell-mediated autoimmune disease. We systemically characterized RORγt binding in the presence and absence of drugs with corresponding whole...
such compounds and pharmaceutical compositions comprising them are suitable means to treat any disease in which rash modulation has therapeutic effects, for example, in autoimmune diseases, diseases related to autoimmunity, inflammatory diseases, metabolic diseases, fibrotic diseases or cholestatic diseases. ...
However, the function of Bob1 in other CD4+ T cell subsets is still unknown. Th17 cells, which produce IL-17 at a high level, are known as critical meditators for the pathogenesis of autoimmune diseases such as multiple sclerosis (MS), inflammatory bowel disease, psoriasis, and rheumatoid...
The main function of Th17 cells is to produce various cytokines, such as IL-17, IL-21 and IL-22, which stimulate epithelial cells, fibroblasts and smooth muscle cells of the airway to secrete CXCL1 and CXCL8, thereby participating in autoimmune diseases [17]. Therefore, Th17 and its ...
Herein, we investigated the differential contributions of eTh17 versus eTh17/1 to the memory pool using an experimental model of ocular autoimmune disease. Our results show that adoptive transfer of Tbx21 -/- CD4 + T cells or conditional deletion of Tbx21 in Th17cells leads to diminished eTh...