抗体药物偶联物(Antibody-Drug Conjugate,ADC)可谓是最近几年来肿瘤治疗领域的“宠儿”。通过连接子将可靶向肿瘤相关抗原的抗体和具有细胞毒性的有效载荷相连,ADC结合了单抗的特异性靶向能力和细胞毒性药物的强效杀伤作用,成为了打击肿瘤的“魔法子弹”。 自第一款ADC药物——Gemtuzumab ozogamicin于2000年在美国获批用于治...
[3] Vaisitti Tiziana, Arruga Francesca, Vitale Nicolettaet al. ROR1 targeting with the antibody-drug conjugate VLS-101 is effective in Richter syndrome patient-derived xenograft mouse models. [J] .Blood, 2021, 137: 3365-3377. [4] NBE-Therapeutics官网,https://www.nbe-therapeutics.com/pipeline...
在此次动物试验中,该药物的疗效也得到了较好的呈现。 (图片来源:《The antibody drug conjugate VLS-101 targeting ROR1 is effective in CAR T-resistant mantle cell lymphoma》) 而本次一线疗法,则称得上惊艳了。 根据II期临床wave...
Molecular Mechanisms Associated with ROR1-Mediated Drug Resistance: Crosstalk with Hippo-YAP/TAZ and BMI-1 Pathways. [J] .Cells, 2019, 8: undefined. [3] Vaisitti Tiziana, Arruga Francesca, Vitale Nicoletta et al. ROR1 targeting with the antibody-drug conjuga...
[11] Islam, S.S., Uddin, M., Noman, A.S.M., et al. Antibody-drug conjugate T-DM1 treatment for HER2+ breast cancer induces ROR1 and confers resistance through activation of Hippo transcriptional coactivator YAP1 [J]. EBioMedicine. 2019, 43, 211–224.[12] Hanna Karvonen, Harlan ...
中文名称:Anti ROR1 Antibody,克隆号LCB71 一、产品描述 Anti ROR1 Antibody,克隆号LCB71,ROR1(receptor tyrosine kinase-like orphan receptor 1)是一种I型跨膜蛋白,属于受体酪氨酸激酶样孤儿受体(ROR)家族。ROR1与核受体中的ROR家族不同,ROR是一类膜受体。它们与家族中的原肌球蛋白激酶受体家族(tropomyosin-rel...
(1)默沙东的zilovertamabvedotin(MK-2140)是人源化IgG1单抗UC961通过一种蛋白酶可切割的连接子马来酰亚胺己酰基−缬氨酸−瓜氨酸−对氨基苯甲酸酯(mc-vc-PAB)与微管聚合抑制剂单甲基奥瑞他汀E(monomethylauristatinE,MMAE)连接起来的抗体偶联药物(antibody-drugconjugate,ADC),DAR均值为4,目前处于临床Ⅲ期。
(1)默沙东的zilovertamab vedotin(MK-2140)是人源化IgG1单抗UC961通过一种蛋白酶可切割的连接子马来酰亚胺己酰基−缬氨酸−瓜氨酸−对氨基苯甲酸酯(mc-vc-PAB)与微管聚合抑制剂单甲基奥瑞他汀E(monomethyl auristatin E, MMAE)连接起来的抗体偶联药物(antib...
2021年8月20日Eileen Y. Hu等人在IMMUNOBIOLOGY AND IMMUNOTHERAPY发表的题为The ROR1 antibody-drug conjugate huXBR1-402-G5-PNU effectively targets ROR1+ leukemia的研究表明,新型ROR1靶向抗体-药物偶联物huXBR1-402-G5-PNU在体外和体内有效抑制 ROR1...
ROR1 targeting with the antibody-drug conjugate VLS-101 is effective in Richter syndrome patient-derived xenograft mouse models. PMID: 33512452 ROR1-STAT3 signaling contributes to ovarian cancer intra-tumor heterogeneity. PMID: 37400436 ROR1, an embryonic protein with an emerging role in cancer biolo...