RORgammat-specific transcriptional interactomic inhibition suppresses autoimmunity associated with TH17 cells. Proceedings of the National Academy of Sciences of the United States of America. 2014Park, T.Y.; Park, S.D.; Cho, J.Y...
Retinoic acid receptor-related orphan receptor (RORt) controls the differentiation of naive CD4(+) T cells into the TH17 lineage, which are critical cells in the pathogenesis of autoimmune diseases. Here we report that during TH17 diffe... H Xiao,Y Wang,LY Hao,... - 《Nature Chemical Biolo...
it was discovered that alternative transcription results in the expression of an isoform, ROR gamma t, which is expressed exclusively in cells of the lymphoid compartment, namely CD4+CD8+ "double-positive" thymoyctes, Th17 cells of the periphery and lymphoid tissue inducer (Lti) cells of lymphoi...
AIMS: Interleukin (IL)-17-producingelper (Th17)ellsaveeen proposedo participate inhe pathogenesisfhronic inflammation,uchsutoimmuneyocarditis. IL-6 geneblationonfersheesistanceo experimentalutoimmuneyocarditis (EAM). Inhistudy, weaveddressedhe pathologicalolesf IL-6 inheegulationfh17ells in EAM.ETH...
作者: M Iizuka,H Tsuboi,N Matsuo,H Asashima,T Hirota,Y Kondo,Y Iwakura,S Takahashi,I Matsumoto,T Sumida 展开 摘要: The nuclear receptor retinoic acid-related orphan receptor (ROR)gamma t is required for the generation of Th17 cells, which are involved in various autoimmune diseases, inclu...
ROR Gamma (T) is expressed only in lymphoid compartment cells, i.e., CD4+CD8+ "double positive" thymocytes, peripheralTh17 cells, and lymphoid tissue inducer (LTi) cells of lymphoid organs. At present, RORγ T is considered as a new target for drug development against autoimmune diseases, ...
Furthermore, it was discovered that alternative transcription results in the expression of an isoform, ROR gamma t, which is expressed exclusively in cells of the lymphoid compartment, namely CD4+CD8+ "double-positive" thymoyctes, Th17 cells of the periphery and lymphoid tissue inducer (Lti) ...
Furthermore, it was discovered that alternative transcription results in the expression of an isoform, RORgammat, which is expressed exclusively in cells of the lymphoid compartment, namely CD4+CD8+ "double-positive" thymoyctes, Th17 cells of the periphery and lymphoid tissue inducer (Lti) cells...
目的：一、了解肝癌患者外周血中是否存在Treg优势化现象。二、研究肝癌患者外周血中Th1、Th2、Th17及Treg各自的主要转录因子T-bet、GATA-3、RORgammat及FOXP3的表达情况。材料与方法：抽取实验组20例肝癌患者与对照组20例健康志愿者的外周静脉血，采用流式细胞术检测外周静脉血单个核细胞中CD4+CD25+T细胞占CD4+细胞...
Furthermore, it was discovered that alternative transcription results in the expression of an isoform, ROR gamma t, which is expressed exclusively in cells of the lymphoid compartment, namely CD4+CD8+ "double-positive" thymoyctes, Th17 cells of the periphery and lymphoid tissue inducer (Lti...