ROR gamma t(+) regulatory T (Treg) cells are critical toward maintaining gut immune tolerance. In recent studies published in Nature, Kedmi et al., Lyu et al., and Akagbosu et al. describe MHCII+ROR gamma t(+) antigen-presenting cells that mediate ROR gamma t(+) Treg cell ...
目的:⑴了解肝癌患者外周血中是否存在Treg优势化现象.⑵研究肝癌患者外周血中Th1,Th2,Th17及Treg各自的主要转录因子T-bet,GATA-3,RORgammat 及FOXP3的表达情况. 方法:抽取实验组20例肝癌患者与对照组20例健康志愿者的外周静脉血,采用流式细胞术检测外周静脉血单个核细胞中CD4+CD25+T细胞占CD4+细胞比例;采用荧光定...
目的：一、了解肝癌患者外周血中是否存在Treg优势化现象。二、研究肝癌患者外周血中Th1、Th2、Th17及Treg各自的主要转录因子T-bet、GATA-3、RORgammat及FOXP3的表达情况。材料与方法：抽取实验组20例肝癌患者与对照组20例健康志愿者的外周静脉血，采用流式细胞术检测外周静脉血单个核细胞中CD4+CD25+T细胞占CD4+细胞...
The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. by expression of specific transcription factors, T-bet for Th1, GATA-3 for Th2, forkhead box P3 (FoxP3) for Tregs and RORgammat for Th17 cells. ... B Afzali,G Lombard...
Chauhan et al., Autoimmunity in Dry Eye is due to Resistance of Th17 to Treg Suppression. J Immunol. Feb. 1, 2009;182(3)1247-52. Chauhan et al., Role of Th17 Cells in the Immunopathogenesis of Dry Eye Disease. Mucosal Immunol. 2009;2(4):375-6. Davidovich et al., Detection of...
T cell-specific Ddx5 knockout (DDX5 Delta T) mice have augmented ROR gamma t+ Treg suppressor activities and are better protected from intestinal inflammation. Genetic ablation or pharmacologic inhibition of HIF1 alpha restores enteropathy susceptibility in DDX5 Delta T mice. The DDX5-HI-F1 ...
alpha(HIF1α)is able to tip the balance of T cell differentiation toward the Th17 lineage by responding to the local changes in metabolic shift or an increase in proinflammatory mediators in the microenvironment.By allying with HIF1α,RORγt wins the fight against FoxP3 and Treg cell ...
TregRegulatory T cells (Tregs) exert inhibitory function under various physiological conditions and adopt diverse characteristics following environmental cues. Multiple subsets of Tregs expressing master transcription factors of helper T cells such as ROR gamma t, T-bet, Gata3 and PPAR gamma have been...
目的：一、了解肝癌患者外周血中是否存在Treg优势化现象。二、研究肝癌患者外周血中Th1、Th2、Th17及Treg各自的主要转录因子T-bet、GATA-3、RORgammat及FOXP3的表达情况。材料与方法：抽取实验组20例肝癌患者与对照组20例健康志愿者的外周静脉血，采用流式细胞术检测外周静脉血单个核细胞中CD4+CD25+T细胞占CD4+细胞...
The inhibitory function of Treg cells of Tg mice was equal to that of wild-type mice in vitro. The abundant Treg cells of Tg mice could suppress the development of sialadenitis, but the reduced Treg cells of Tg mice could not inhibit the induction of sialadenitis in Rag2(-/-) mice ...