Genetic defects in cell adhesion molecules in man and the ability to target gene deletion by homologous recombination in mice have contributed greatly to our understanding of this cascade in the past 20 years.97 Each of the members of the selectin family can support leukocyte rolling under ...
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LAMP achieves high-efficiency detection by using four specific primers to target six regions of the target at 60–65°C. The primer design is relatively complicated, and false positive problems are prone to occur due to high amplification efficiency. CPA is another isothermal amplification method ...
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The process of leukocyte adhesion in vivo consists of dynamic adhesion (rolling on endothelial wall) followed by stable adhesion and extravasation into the target organ. Rolling is mediated by transient interactions between adhesion molecules on the leukocyte surface and their receptors on the endothelium...