Roles of RNA scaffolding in nanoscale Gag multimerization and selective protein sorting at HIV membranesdoi:10.1126/sciadv.adk8297HIV-1 Gag proteins can multimerize upon the viral genomic RNA or multiple random cellular messenger RNAs to form a virus particle or a virus-like particle, ...
Although RIPK1 is a kinase, most of its signaling pathways do not actually require its kinase activity52 but rather its function as a scaffolding protein. An exception to this is its signaling role in necroptosis. The assembly and activation of the RIPK1-RIPK3 complex downstream of TNF-α ...
The biogenesis of exosomes is tightly regulated through a complex network of processes. Upon endocytosis, the potential cargos are internalized by the cells and give rise to early-sorting endosomes (ESEs). The subsequent interactions with organelles, such as the endoplasmic reticulum (ER) and Golgi...
The long noncoding RNA (lncRNA) X-inactive specific transcript (XIST) is involved in X chromosome inactivation (XCI) in female placental mammals, a process that ensures the balanced expression dosage of X-linked genes between sexes. XIST is abnormally expressed in many sex-biased diseases. In...
to immune evasion.61In OSCCs, exosomal circular RNA circ_0069313 could increase the PD-L1 expression in cancer cells with miR-325-3p sponging and interact with Treg cells. Thus, the Teff cells are suppressed, while the Treg cells are activated, resulting in the immune escaping of malignancy....
In recent years, a type of non-coding regulatory RNA molecule known as circular RNAs (circRNAs) has been reported. These molecules are produced during back splicing and possess significant biological capabilities, such as regulating microRNA activity, serving as protein scaffolds and recruiters, ...
Dean et al. found that recruitment of neurexin mutants lacking cytoplasmic tails containing PDZ domains could not lead to effective presynaptic differentiation [41]. All these indicate that presynaptic or postsynaptic differentiation is largely dependent on the interaction of scaffolding proteins with NLs ...
Finally, we have demonstrated that viral dsRNAs were also localized in VLS in infected cells, suggesting that NSs-formed VLS may he implicated in the replication of SFTS bunyavirus. These findings identify a novel function of nonstructural NSs in SFTSV-infected cells where it is a scaffolding ...
1b,c), presumably because of the dominant cytoplasmic localization of GAPDH. Since TrkB localizes to the postsynaptic density (PSD) of excitatory synapses that contains receptors and their associated signalling and scaffolding proteins2,18, we then examined TrkB expression in the PSD fraction. We ...
Metastasis accounts for the majority of cancer-related deaths. Actin dynamics and actin-based cell migration and invasion are important factors in cancer m