Most breast cancers are driven by oestrogen receptor-伪. Anti-oestrogenic drugs are the standard treatment for these breast cancers; however, treatment resistance is common, necessitating new therapeutic strategies. Recent preclinical and historical clinical studies support the use of progestogens to ...
Oestrogen, Progesterone and Serotonin Converge on GABAergic Neurones in the Monkey Hypothalamus neurones in regions of the primate hypothalamus that have been implicated in the neuroendocrine control of prolactin and luteinizing hormone (LH) secretion. ... Mirkes,J S.,Bethea,... - 《Journal of ...
1936). Bergström, Samuelsson and co-workers have since found seminal plasma to contain many different prostaglandins, with PGE1and PGE2being the most abundant in both human and sheep semen. The physiological significance of seminal prostaglandins in reproduction is...
While the cervix is a hormone-sensitive tissue, physiologic roles of estrogen receptor α (ERα), progesterone receptor (PR), and their ligands in this tissue are poorly understood. It has hampered critical assessments of data in early epidemiologic and clinical studies for cervical cancer. ...
Controlled oxidation, such as disulfide bond formation in sperm nuclei and during ovulation, plays a fundamental role in mammalian reproduction. Excess oxidation, however, causes oxidative stress, resulting in the dysfunction of the reproductive process.
In humans there are some obvious physical differences in reproductive systems and physique but also some less obvious differences in physiological processes i.e. the sex hormones testosterone, oestrogen and progesterone. W... Wordcount: 1936
Triple???negative breast cancer (TNBC) refers to the breast cancers that express little human epidermal growth factor receptor 2 (HER2), progesterone receptor (PR) and oestrogen receptor (ER). When compared to other types of breast cancers, TNBC behaves more aggressively with relatively poorer pro...
Establishment of pregnancy in pigs involves maintaining progesterone secretion from the corpora lutea in addition to regulating a sensitive interplay between the maternal immune system and attachment of the rapidly expanding trophoblast for nutrient absorption. The peri-implantation period of rapid trophoblasti...
The uterus exhibits a unique structural and physiological plasticity when responding to ovarian cues with orderly cycles of tissue differentiation, glandular secretion, and regional turnover of terminally differentiated cells. These cyclic changes are pr
ER has two different subtypes, ERα and ERβ, which belong to the superfamily of nuclear HR and act as a transcription factor regulated mainly by oestrogen [47]. Between these two receptors, ERα is encoded by ESR1 and essential for the tumourigenesis and malignancy of luminal subtype of BC...