From databases and literature, the expressions and mutations of MT-ND1 in a variety of cancers have been reviewed. MT-ND1 may be a biomarker for cancer diagnosis and prognosis. It is also a potential target for cancer therapy.doi:10.1007/s11596-023-2771-0Yi-chun Xu...
Enhancer reprogramming in cancer not only unlocks the phenotypic plasticity of cancer cells, enabling traits such as proliferation, drug resistance, and metastasis but also contributes to the reshaping of the tumor microenvironment, driving cancer progression through more complex mechanisms. Based on previo...
Enhancer reprogramming in cancer not only unlocks the phenotypic plasticity of cancer cells, enabling traits such as proliferation, drug resistance, and metastasis but also contributes to the reshaping of the tumor microenvironment, driving cancer progression through more complex mechanisms. Based on previo...
Table 1. Role of mitochondrial contents in EVs. OriginTypes of EVsContentTarget cell/tissueEffectsDisease modelRef Cancer-associated fibroblast Exos mtDNA HTR cancercells Promote metabolism/OXPHOS capacity Breast cancer [82] Antiphospholipid antibodies -exposed placental explants Exos and MVs mtDNA Endotheli...
3. Structure and biological functions of CDK12 4. Oncogenic functions of CDK12 in human malignancies 5. Tumor-suppressive roles of CDK12 in human cancers 6. Pharmacological targeting CDK12 in cancer 7. Conclusion Declaration of Competing Interest Acknowledgements Appendix A. Supplementary data Referenc...
(3′-UTR) of their target mRNAs.12 MiRNAs have been found to serve as tumor suppressors or oncogenes in various cancer types and clinical prognoses.13–15 In NSCLC, several deregulated miRNAs, such as miR-34a, let-7, miR-124 and miR-154, have been shown to regulate cell proliferation,...
clinical treatment for leukemias are 'hot' and difficult research directions in the field of cancer. STAT proteins (STATs) belong to a family of transcription factors that are activated by polypeptide ligands, such as cytokines and growth factors. STATs comprise seven members: STAT1, STAT2, STAT3...
cancer cells, combined with functional assays. This led us to propose novel roles for JUNB activity in the regulation of both cell cycle and tumor progression. We show a positive role of JUNB in cell cycle progression via induction of the cyclin E1 gene (CCNE1) and repression of the TGF-...
Future Perspectives The role of ncRNAs in cancer has been well established, however, their function during infection has only been reported for specific viruses [83, 84]. In this review, we 13 Roles of Non‑Coding RNAs in Virus‑Host Interaction About Pathogenesis of Hand‑Foot‑...
in the regulation of apoptosis and autophagy in cancer. In this review, we summarize that certain oncogenic and tumor suppressive miRNAs could modulate apoptotic pathways in different types of cancer. Subsequently, we demonstrate that other miRNAs might play regulatory roles in the autophagic pathways ...