Iron is vital for almost all living organisms by participating in a wide variety of metabolic processes, including oxygen transport, DNA synthesis, and electron transport. However, iron concentrations in body tissues must be tightly regulated because excessive iron leads to tissue damage, as a ...
Iron regulatory proteins (IRP) modulate the use of mRNA-encoding proteins that are involved in the transport, storage and use of iron. Several new potential mRNA targets for IRP were recently identified: divalent metal transporter-1 (DMT-1) and ferroportin, which are critical regulators of iron...
We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media. By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some...
With a growing body of evidence supporting the involvement of ferroptosis in autoimmune diseases, it is apparent that this cellular demise pathway is ubiquitously present and pivotal in the pathogenesis of autoimmune disorders [13, 14]. Ferroptosis is a newly characterized iron-dependent form of progr...
Given the importance of iron in the context of fundamental physiology, the levels of iron both within cells and in the body as a whole are stringently regulated, and the processes of iron absorption, transfer, storage, and retrieval by multiple mechanisms are finely balanced (Fig.1A). In mamm...
By functioning as an iron mimetic, gallium perturbs iron-dependent proliferation processes in tumor cells. Gallium's action on iron homeostasis leads to disruption of ribonucleotide reductase, mitochondrial function, and the regulation of transferrin receptor and ferritin. In addition, gallium nitrate ...
a在最大程度上 In greatest degree [translate] aa work of fact 事实工作 [translate] a他喝了带蜂蜜的水,感觉好多了 He has drunk the belt honey water, felt was much better [translate] aSouth Bank Road, Guangzhou City, Guangdong decorative materials showcase 309 stalls of iron steel wood Show...
The 5 most powerful Iron Man villains, ranked from weakest to strongest Kevin Hart is mistaken for a killer in The Man From Toronto Netflix unleashes an action-packed trailer for The Gray Man
It has also been proposed that caloric restriction can delay sarcopenia by reducing oxygen radical production, decreasing oxidative stress damage, enhancing mitochondrial function, improving protein homeostasis, reducing iron overload, increasing autophagy and apoptosis, and reducing inflammation [286]. In ...
iron overload, which can cause various pathological states [15]. The main sources of iron in the human body can be divided into exogenous iron and endogenous iron [16]. Dietary iron, also known as exogenous iron, is absorbed mainly in the duodenum and upper jejunum, and this accounts for...