Enzymes in bile acid synthesis also metabolize very long chain fatty acids , such as dietary pristanic acid, and in agreement with the dual functional roles of these proteins, gene mutations that impair these enzyme activities cause defects in hepatic bile acid synthesis5 and the accumulation of...
What is the role of the blood in the regulation of pH of the body? How do things like diet and nutrition affect the nervous system and/or do they? What are the jobs and duties of neurotransmitters? Describe the role of bile salt in lipid digestion. ...
The main synthesis and circulation of BA in periphery and brain are summarized in Fig. 1. Fig. 1 Metabolism and circulation of bile acids in periphery and brain. The catabolism of cholesterol to primary bile acids (BA) in liver by two path- ways, involving the critical enzymes ...
Notably, PTMs are also involved in the regulation of bile acid metabolism, which is the main pathway for cholesterol utilization. The Farnesoid X receptor (FXR), which transcriptionally regulates genes involved in bile acid metabolism, is essential in maintaining bile acid homeostasis. Byun et al....
Diet and the composition of the gastrointestinal microbiome affect each other in children and adults [53,62,63,64]. For example, having an animal-based diet increases abundance of bile-tolerant microorganisms (Alistipes, Bilophila, and Bacteroides) and decreases levels of polysaccharides metabolizers ...
Cholesterol is vital to the function of the brain and nervous system. Cholesterol protects us against depression; it plays a role in the utilization of serotonin, the body'sfeel goodchemical. The bile salts, needed for the digestion of fats, are made of cholesterol. ...
[174]. Gut microbiota is the main mediator of the gut-brain axis in the regulation of glucose homeostasis. It contributes to glucose homeostasis by regulating the immune system, inflammatory response, modulation of incretin secretion, production of SCFA, and metabolism of bile acids [171]. Gut ...
Mitophagy is a process in which impaired or dysfunctional mitochondria are selectively eliminated through the autophagy mechanism to maintain mitochondrial quality control and cellular homeostasis. Based on specific target signals, several mitophagy proc
Long-term effects of roux-en-Y gastric bypass on postprandial plasma lipid and bile acids kinetics in female non diabeticsubjects: a cross-sectional pilot study. Clin Nutr. 2015;34:911–7. Article PubMed Google Scholar Egerod KL, Engelstoft MS, Grunddal KV, Nøhr MK, Secher A, ...
Transphobia is an under-examined but important type of prejudice to study in Polish culture. Poland is a country where a majority of transgender people fee