The hydroxy-carboxylic acid (HCA) receptors HCA(1), HCA(2), and HCA(3) were previously known as GPR81, GPR109A, and GPR109B, respectively, or as the nicotinic acid receptor family. They form a cluster of G prot
With the emerging evidences of crucial connec- tions between the gut microbiota and the brain function or neurological disorders, the microbiota metabolites BA are possible to function as an important communication channel in the gut-brain axis [39, 40]. Recently, the presence of multiple primary ...
The mechanism of cardiovascular diseases (CVDs) is complex and threatens human health. Cardiomyocyte death is an important participant in the pathophysiological basis of CVDs. Ferroptosis is a new type of iron-dependent programmed cell death caused by ex
Traditionally, lactate has been considered a ‘waste product’ of cellular metabolism. Recent findings have shown that lactate is a substance that plays an indispensable role in various physiological cellular functions and contributes to energy metabolism and signal transduction during immune and inflammator...
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Further examination of parental cells revealed that the 63 kDa isoform was much more abundant than the full-length iPLA2γ in HEK293 and human colorectal cancer cell lines, HCA-7 and WiDr, while in human bronchial epithelial (BEAS-2B) and rat fibroblastic (3YI) cells, the full-length iPL...
The roles discussed in this section refer to HMC users; operating systems running on logical partitions has its own set of users and roles. Each HMC user has an associated task role and a resource role. The task role defines the operations the user can perform. The resource role defines ...
Cytoplasmic lipogenesis and cholesterol synthesis are nonoxidative metabolic fates of ketone bodies. mThiolase or cytosolic thiolase (cThiolase) activity is encoded by at least six genes: ACAA1, ACAA2 (encoding an enzyme known as T1 or CT), ACAT1 (encoding T2), ACAT2, HADHA, and HADHB. ACS...
Anthocyanin is an important class of water-soluble pigments that are widely distributed in various tissues of plants, and it not only facilitates diverse color changes but also plays important roles in various biological processes. Maize silk, serving as
β2-integrins are adhesion- and mechanoreceptors expressed exclusively on leukocytes. They mediate diverse functions in immunity and are of fundamental importance in processes such as leukocyte trafficking, phagocytosis, T cell and B cell activation and.