This review discusses the role of the multifunctional DNA/RNA-binding protein YB-1 in inflammation. YB-1 performs multiple functions in the cell depending on its location: it acts as transcriptional factor for many genes in the nucleus, regulates translation and stability of mRNA in the cytoplasm...
作者: YB Shaik-Dasthagirisaheb,P Conti 摘要: Immunity and inflammation are deeply involved in Alzheimer's disease. The most important properties of pathological Alzheimer's disease are the extracellular deposits of amyloid -protein plaque aggregates along with other unknown mutated proteins, which ...
In the 1990s, an enhancer detection screen identified a new gene, Castor, which is required for the development of the central nervous system in Drosophila embryos [1]. The Castor zinc finger protein is expressed in subsets of the Drosophila ventral nerve chord and the procephalic region during...
cIAP1 and cIAP2 have a CARD domain (CAspase Recruitment Domain), which is also present in various components of apoptotic and inflammation signaling complexes like caspases (-1/-2/-4/-5/-9 and -13), Apaf-1, PIDD, RAIDD, NODs and RIP2. The role of CARD domain in IAPs has been ...
However, both the roles of these proinflammatory cytokines, and the most important cellular sources of their production, can vary according to the models of inflammation analyzed. For example, in mice, mast cell-derived TNF has been reported to contribute importantly to neutrophil recruitment and ...
1. Do intracellular pathogens block degradation of mitophagosome in the way like disturbing xenophagy? 2. Is mitophagy dysfunction crucial for mild to severe infections? 3. How to balance anti-inflammation (mitophagy) and pro-inflammation (mitochondria) in the infectious diseases? 4. Can extrac...
cell effector functions, thereby highlighting the key role of LDH in inflammation [72]. Changes in LDHB expression are often associated with early metabolic adaptation [73]. LDHB-mediated LA use supports autophagy to maintain metabolic health and cancer cells growth [74], indicating that the ...
Osteoporosis is a widely observed condition characterized by the systemic deterioration of bone mass and microarchitecture, which increases patient susceptibility to fragile fractures. The intricate mechanisms governing bone homeostasis are substantially
Usage of cinacalcet was shown to significantly abolish the up-regulation of mesenchymal markers (fibroblast-specific protein 1 and α-SMA) and the down-regulation of the endothelial marker (CD31), resulting in attenuation of VC in uremic aorta samples [13]. When stimulated with transforming growth...
Monitoring disease progression is crucial to preventing relapse, but is often complicated by the lack of clinical symptoms in the setting of active disease. Although acute phase reactants such as ESR and CRP are generally used as an indicator of inflammation and disease activity, mounting evidence...