胱氨酸(e)酶介导的胱氨酸(e)耗竭可在小鼠胰腺导管腺癌衍生细胞系和突变型Kras/Tp53驱动的胰腺肿瘤中诱导铁死亡,而不引起明显的毒性,表明可接受的安全性和耐受性。这种方法也抑制EGFR突变非小细胞肺癌细胞株和乳腺癌异种移植物的肿瘤生长。使用胱氨酸(e)酶调节胞外胞胱氨酸(e)水平的策略可以为基于铁死亡的抗癌治疗开...
Abdominal aortic aneurysm (AAA) is a life-threatening disease associated with high morbidity, and high mortality in the event of aortic rupture. Major adva... J Raffort,F Lareyre,M Clement,... 被引量: 0发表: 2013年 Controversies in the management of type II "branch" endoleaks following ...
Osmotic stress generated by drought and high-salinity conditions promotes the accumulation of ABA in plant cells and the activation of the ABA signalling pathway. The core molecular components of ABA perception and signal transduction have been well studied1,2,3. Following prior studies of sucrose n...
P Andreuccetti - 《Journal of Morphology》 被引量: 99发表: 1992年 Cytokeratin cytoskeleton in the differentiating ovarian follicle of the lizard Podarcis sicula Raf. By immunoblotting and immunocytochemical techniques, we characterized the cytokeratins previously localized by us in the previtellogenic ...
5. Role of Epacs in modulating cAMP signaling 6. Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels 7. Guanylate cyclases: regulation, tissue distribution and participation in neuronal function 8. Role of PKG in synaptic plasticity and memory 9. Regulation of the intracellular concentr...
MicroRNAs(miRNAs), which are also non-coding RNAs, are short single-stranded RNAs, usually composed of 18–23 nucleotides. MiRNAs inhibits gene expression by specifically binding to the 3′-UTR of downstream target mRNAs and can function as oncogenes or suppressor oncogenes to regulate the ...
三个早期临床前观察支持某些致癌信号和铁死亡诱导之间的联系:(1)铁死亡激活剂erastin被鉴定,因为它能够选择性地在含有突变型而非野生型RAS的癌细胞中触发细胞死亡;(2)RAS-RAF-MEK-ERK通路的激活是erastin诱导的细胞死亡所必需的和(3)铁,已知对癌细胞增殖很重要,也是erastin诱导的细胞死亡所必需的。随后的研究发现了...
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RAF proto-oncogene serine/threonine-protein kinase CRL7: Cullin-RING E3 ubiquitin ligase 7 CUL1: Cullin1 CUL7: Cullin 7 DECL: DNA-encoded compound libraries DISC: Death-inducing signaling complex DLBC: Lymphoid neoplasm diffuse large B-cell lymphoma ...
Exosomes are vesicles encompassed by a lipid bilayer that are released by various living cells. Exosomal proteins are encapsulated within the membrane or embedded on the surface. As an important type of exosome cargo, exosomal proteins can reflect the ph