The percentage of Th1 cells in advanced stage of chronic hepatitis B was higher than that in stable stage of chronic hepatitis B. The percentage of Th2 cells in CD4+ T cells from HBV-infected individuals did not differ significantly, but higher than that from controls Conclusion: The results...
Although NKT cells can modulate disease outcomes through the release of Th1-, Th2-, and Th17-related cytokines, it is also possible that regulatory NKT cells in the pulmonary mucosa have a crucial role, for instance, by controlling the production of harmful cytokines. A better characterization ...
gastric, and pancreatic cancers) as well as non-gastrointestinal cancers (such as lung, breast, and melanoma cancers). Due to the innate anatomical position of the liver, the apoptosis of T cells in the liver, the unique metabolic regulation of hepatocytes and other potential mechanisms,...
Evidence is accumulating that Th1 cells play an important role in the development of multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE), whereas Th2 cells contribute to recovery from disease. A major determinant in the development of Th1 and Th2 cells is the type of antigen...
T-bet-deficient T cells tended to differentiate toward Th17 cells in vitro following exposure to MAC. Treatment with NO donor suppressed MAC-induced Th17 cell differentiation of T-bet-deficient T cells. This study identified that the fine balance between Th1 and Th17 responses is essential in ...
of Th1 and Th17 cytokines in CD4+T cells in mesenteric lymph node were determined by flow cytometry.Results: DAI in mice with experimental colitis was increased gradually with the progression of disease and reached the peak until day 7.Compared with the normal controls,expression of IL-1β ...
Influenza virus infection is among the most detrimental threats to the health of humans and some animals, infecting millions of people annually all around the world and in many thousands of cases giving rise to pneumonia and death. All those health crise
Non-Responsiveness to Mercury-Induced Autoimmunity in Resistant DBA/2 Mice is not Due to Immunosuppression or Biased Th1-Type Response. However, certain resistant mouse strains do not show any of the autoimmune manifestations after mercury injection. Th1/Th2 dichotomy has been proposed to ... HU,...
Similar to classical type 1 helper T (Th1) cells, MAIT cell effector functions are governed by transcription factors T-bet, eomesodermin (Eomes), and B-lymphocyte-induced maturation protein 1 (Blimp-1), controlling their Th1-profile and secretion of interferon (IFN)γ/tumour necrosis factor (...
& Arai, N. Ectopic expression of activated STAT-6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells. Immunity 11, 677–688 (1999). Article CAS PubMed Google Scholar Ranger, A.M. et al. Delayed lymphoid repopulation with defects in IL-4-...