The role of testosterone in the pathogenesis of prostate cancer. Int. J. Urol. 15 : 472-480.Imamoto T, Suzuki H, Yano M, Kawamura K, Kamiya N, Araki K, Komiya A, Nihei N, Naya Y, Ichikawa T. The role of testosterone in the pathogenesis of prostate cancer. Int J Urol. 2008; ...
testosterone is converted into a more potent 5α-reduced metabolite of testosterone, 5α-dihydrotestosterone (DHT), which promotes the growth and survival of prostate cells. DHT binds to the AR with high affinity, displaces heat-shock proteins from the AR, drives the interaction between the N a...
Genome organization of the human androgen receptor gene and the functional domain structure of the androgen receptor protein. (A) Androgen and AR signaling in prostate cells. After testicular synthesis, testosterone is transported to target tissues such as the prostate and becomes converted to ...
Prostate cancer is the second most common cancer diagnosed in men and the fifth-leading cause of cancer death in men worldwide. Like any solid tumor, the hypoxic microenvironment of prostatic cancer drives hypoxia-inducible factors (HIFs) to mediate cell adaptions to hypoxic conditions. HIFs direc...
Androgens play a critical role in the development and progression of prostate cancer (PCa), and androgen deprivation therapy via surgical or medical castration is front-line therapy for patients with advanced PCa. However, intratumoral testosterone levels are elevated in metastases from patients with ca...
6) Testosterone gets converted into estrogen via the aromatase enzyme and normal levels of estrogen may have a beneficial impact on the arterial wall in men. Prostate cancer and testosterone: Concern about the risk of prostate cancer is still the primary reason many practitioners get nervous about...
To date, only few data concerning the biologically active, free form of testosterone (FT) are available in metastatic prostate cancer (mPC) and the impact of FT on disease, therapy and outcome is largely unknown. We retrospectively studied the effect of
On stimulation of CAFs with testosterone, the AR binds at CCL2 and CXCL8 loci, thereby down-regulating the CCL2 and CXCL8 genes and regulating PC migration and invasion.55 ECM is the noncellular matrix component of the tissue that provides structural and metabolic support to the cellular ...
The global burden of prostate cancer (PC) is substantial, ranking among the top five cancers for both incidence and mortality [1]. It is particularly common in developed Countries since, in addition to individual biological and genetic factors, environment and lifestyle impact the risk of developi...
Models used in cancer research can be naturally occurring or artificially induced, designed in such a way that they share genetic and phenotypic characteristics with cancer of humans. Animal models serve as templates or experimental setups allowing the e