Fernández-García S, Sancho-Balsells A, Longueville S et al (2020) Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy. Cell Death Dis 11(6):411. https://doi.org/10.1038/s41419-020-2615-9 Article CAS PubMed PubMed Central Google Scho...
Repetitive DNA sequences playing critical roles in driving evolution, inducing variation, and regulating gene expression. In this review, we summarized the definition, arrangement, and structural characteristics of repeats. Besides, we introduced diverse
In the post-genomic era, the data provided by complete genome sequencing could not answer several fundamental questions about the causes of many noninfectious diseases, diagnostic biomarkers, and novel therapeutic approaches. The rapidly expanding understanding of epigenetic mechanisms, as well as widespre...
and analgesia - insights gained through human functional imaging David Borsook*1, Jaymin Upadhyay1, Eric H Chudler2 and Lino Becerra1 Abstract The basal ganglia (BG) are composed of several nuclei involved in neural processing related to the execution of motor, cognitive and emotional activities....
disorders [e.g., Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), Wallerian neurodegeneration and spastic paraplegia]. Deficits or pathogenic mutations in BEACH-containing proteins other than WDFY3 in humans (Fig.2B) are associated with bipolar disorder, schizophrenia, epilepsy, ASD,...
2. Enzymes of the detyrosination/re-tyrosination cycle 3. Physiological impact of the detyrosination/re-tyrosination cycle on neurons and brain 4. Physiological impact of the cycle in cardiomyocytes and heart 5. Dysfunction of the cycle leads to brain and heart diseases 6. Concluding remarks...
2. The economic value of the scuba diving industry The scuba diving industry is a crucial component of island states blue economy sectors. Scuba diving, notably on coral reefs and to view iconic marine species, represents a lucrative business attraction. It underpins the tourism sector in many ...
Prescription of metformin in a time-dependent manner stimulates the differentiation of BMPCs into osteoblast by activating specific osteoblast transcription factors, such as Runx2/Cbfa1 and activating AMPK (Molinuevo et al. 2010). As the activation of AMPK was intensified by metformin, phosphorylation...
Repetitive DNA sequences playing critical roles in driving evolution, inducing variation, and regulating gene expression. In this review, we summarized the definition, arrangement, and structural characteristics of repeats. Besides, we introduced diverse
In light of the role of an RDN in KD therapy in epilepsy, future research should also examine the role of RDNs in improving KD compliance and safety among individuals with PD. 5. Mediterranean Diet The MD may play a beneficial role in disease prevention, and several studies support its ...