In other words, while genetics refers to the study of genotypes, epigenetics can refer to the studies of phenotypes resulting from environmental and/or other factors that can switch the intensity and timing of gene expression on and off (Cervantes and Sassone-Corsi2019). Now, the term “epigen...
Fernández-García S, Sancho-Balsells A, Longueville S et al (2020) Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy. Cell Death Dis 11(6):411. Kotliarova A, Sidorova YA (2021) Glial cell line-derived neurotrophic factor family ligands...
and analgesia - insights gained through human functional imaging David Borsook*1, Jaymin Upadhyay1, Eric H Chudler2 and Lino Becerra1 Abstract The basal ganglia (BG) are composed of several nuclei involved in neural processing related to the execution of motor, cognitive and emotional activities....
Repetitive DNA sequences (repeats) are patterns of nucleic acids that occur in multiple copies throughout the genome1. Both eukaryotic and prokaryotic organisms contain a certain proportion of repeats in the genome2,3,4, particularly mammalians, in which repeats account for 25–50% of their enti...
disorders [e.g., Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), Wallerian neurodegeneration and spastic paraplegia]. Deficits or pathogenic mutations in BEACH-containing proteins other than WDFY3 in humans (Fig.2B) are associated with bipolar disorder, schizophrenia, epilepsy, ASD,...
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths reported worldwide. The incidence is higher in Asia and Africa, where there is greater endemic prevalence of hepatitis B and C. The devastating outcome of cancer can be minimized
2. Enzymes of the detyrosination/re-tyrosination cycle 3. Physiological impact of the detyrosination/re-tyrosination cycle on neurons and brain 4. Physiological impact of the cycle in cardiomyocytes and heart 5. Dysfunction of the cycle leads to brain and heart diseases 6. Concluding remarks...
2. The economic value of the scuba diving industry The scuba diving industry is a crucial component of island states blue economy sectors. Scuba diving, notably on coral reefs and to view iconic marine species, represents a lucrative business attraction. It underpins the tourism sector in many ...
Ogawa, K., Yumoto, R., Hamada, N., Nagai, J., & Takano, M. (2006). Interaction of valproic acid and carbapenem antibiotics with multidrug resistance-associated proteins in rat erythrocyte membranes. Epilepsy Research, 71, 76–87. Article PubMed CAS Google Scholar Omote, H., & Al-Shaw...
Repetitive DNA sequences playing critical roles in driving evolution, inducing variation, and regulating gene expression. In this review, we summarized the definition, arrangement, and structural characteristics of repeats. Besides, we introduced diverse