Role of SRY gene for sex determination in farm animalsDongre, V.BAhlawat, A.R
only the testis-specific circRNA from the sex-determining region Y (Sry) was considered functional (in mouse testes) [22,23]. However, in recent years, the adoption of high-throughput RNA sequencing (RNA-seq) and circRNA-specific bioinformatics algorithms has enabled...
What is the role of the SRY gene in humans?A、It initiates the X inactivation process in females. B、It is located on the X chromosome and causes the X to pair with the Y chromosome during male meiosis. C、It is located on the Y chromosome and initiates the developmental pathway toward...
A proximal promoter construct for the MAS gene was repressed by the SOX [SRY (sex-determining region on the Y chromosome) box] proteins SRY, SOX2, SOX3 and SOX14, of which SRY is known to interact with the KRAB domain. The KRAB-KAP-1 complex can be tyrosine-nitrated, causing the ...
In LUAD, regulation of the expression of the glycolysis-related gene ENO1 suppresses tumor activity [71], and inhibition of ENO1 expression suppresses the proliferation of LUAD cells [72], and down-regulation of ENO1 expression reduces the activation of AKT1 phosphorylation, which subsequently in...
Forty-six ,XY Differences/Disorders of Sex Development (DSD) are characterized by a broad phenotypic spectrum ranging from typical female to male with undervirilized external genitalia, or more rarely testicular regression with a typical male phenotype.
In most mammals, sex is genetically determined by the presence or absence of the Y chromosome. Sry was discovered in 1990 as the only gene on the Y chromosome required to initiate male development. SRY is a member of the SOX transcription factor family. However, despite much characterisation ...
In mammals, the sex determining SRY gene directs the development of male gonads by encoding a transcription factor that upregulates other transcription factors like SOX9, ultimately leading to the development of the seminiferous tubes that make sperm. A downstream target of SRY/SOX 9 is DMRT1 (...
The complex interaction between circadian rhythms and physiological functions is essential for maintaining human health. At the heart of this interaction lies the PERIOD proteins (PERs), pivotal to the circadian clock, influencing the timing of physiolog
The Cyclin-dependent kinase (CDK) class of serine/threonine kinases has crucial roles in the regulation of cell cycle transition and is mainly involved in the pathogenesis of cancers. The expression of CDKs is controlled by a complex regulatory network c