However, the important role of sebaceous gland–derived lipids in skin inflammatory diseases may be underrecognized. This overview focuses on the importance of the contribution of sebaceous glands to barrier function. Sebaceous gland alteration may play a role in the pathogenesis of common skin ...
An update on the role of the sebaceous gland in the pathogenesis of acnedoi:10.4161/derm.3.1.13900The pathogenesis of acne, a disease of the pilosebaceous follicle and one of the most common chronic skin disorders, is attributed to multiple factors such as increased sebum production, alteration...
What is the role of sebaceous glands? View Solution Consider the following three statements related to the human male reproductive system and select the correct option stating which ones are true (T) and which ones are false (F). Middle piece of spermatozoon is also termed as power house of...
sebaceous glandsebocyte target therapyThe androgen receptor plays a pivotal role in the sebaceous glands. Its primary function is to stimulate cell proliferation and differentiation in the sebaceous and its associate with acne. Previous studies have demonstrated expression of AR and steroidogenic enzymes ...
Androgen can stimulate growth and lipid synthesis of the sebaceous gland. 5α-reductase converts testosterone to potent androgen-dihydrotestosterone(DHT),and DHT further promotes lipids secretion of the sebaceous gland,which plays an important role in the pathogenesis of acne. In this paper,the findin...
Muir-Torre syndrome is an autosomal-dominant skin condition of genetic origin, characterised by tumours of the sebaceous gland or keratoacanthoma that are ... G Ponti,MPD Leon - 《Lancet Oncology》 被引量: 318发表: 2005年 Value of MLH1 and MSH2 mutations in the appearance of Muir-Torre sy...
Khodr B, Khalil Z (2001) Modulation of inflammation by reactive oxygen species: implications for aging and tissue repair. Free Radic Biol Med 30:1–8 ArticlePubMedCASGoogle Scholar Thiele JJ, Weber SU, Packer L (1999) Sebaceous gland secretion is a major physiologic route of vitamin E delive...
If, indeed, increased FGFR2 signaling plays a major pathogenic role in follicular hyperkeratinization and sebaceous gland hypertrophy in acne, effective anti-... BC Melnik,G Schmitz,CC Zouboulis - 《Journal of Investigative Dermatology》 被引量: 87发表: 2009年 Modulators of UDP-glucose ceramide ...
The mouse aldehyde oxidase AOH2 (aldehyde oxidase homolog 2) is a molybdoflavoenzyme. Harderian glands are the richest source of AOH2, although the protein is detectable also in sebaceous glands, epidermis, and other keratinized epithelia. The levels of AOH2 in the Harderian gland and skin ar...
For example, in HPV-associated vulvar sebaceous gland differentiated intraepithelial carcinoma, infection with HPV type 16 virus induces the expression of ARs and makes the cells more sensitive to androgens.72 In summary, research has shown an inverse correlation between HPV infection and decreased ...