miRNAs work as small guide molecules in RNA silencing, by negatively regulating the expression of several genes both at mRNA and protein level, by degrading their mRNA target and/or by silencing translation. One of the most recent advances in the field is the comprehension of their role in ...
Finally, we describe how particular properties of these regulatory complexes regulate translation initiation.Thomas GeissmannStefano Marzi & Pascale RombyRNA BiologyGeissmann, T, Marzi, S, Romby, P (2009) The role of mRNA structure in translational control in bacteria. RNA Biol 6: pp. 153-160...
As a result, several regions of rRNAs from both ribosomal subunits were implicated in termination. More specifically, the mutation G1093A in an RNA of the large subunit (23S rRNA) and the mutation C1054A in the small subunit RNA (16S rRNA) of the ribosome, were shown to affect the ...
This supposition is based on the following observations: (1) When rel − cells are shifted down in carbon or nitrogen source, the stringent control of RNA synthesis is observed in spite of their rel − genotype2,4. Only when deprived of amino acids do rel − cells fail to restrict ...
Translation repression and decay are still carried out in yeast lacking key P-body components. Similarly, in cells lacking P-bodies, bulk mRNA decay, non-sense mediated mRNA decay, and RNA-mediated gene silencing still occur [136], [137]. Recent evidence suggests that P-bodies are primarily ...
Because of these data, and because viral RNA is presumably not translated by an IRES mechanism, it has been suggested that VPg plays a role in translation of viral RNA. Studies described herein were initiated to investigate the potential role for Norwalk virus (NV) VPg in this process. It ...
Translational control at the synapse: role of RNA regulator Translational control of gene expression is instrumental in the regulation of eukaryotic cellular form and function. Neurons in particular rely on this for... A Iacoangeli,H Tiedge - 《Trends in Biochemical Sciences》 被引量: 53发表: ...
In this work first hints are given that the efp promoter contains a repressor site, and that expression of yjeA and yjeK is dependent on the pH of the medium and the presence of the small RNA binding protein Hfq. This leads to the suggestion that small regulatory RNAs are also involved ...
To initiate protein translation, a ribosome binds and assembles an initiation complex in the area of the gene start codon1. When monocistronic mRNA encoding a single gene is translated, spatial considerations that could interfere with ribosome binding are largely irrelevant. However, in bacteria, ...
Over 150 types of RNA modifications are identified in RNA molecules. Transcriptome profiling is one of the key steps in decoding the epitranscriptomic panorama of these chemical modifications and their potential functions. N7-methylguanosine (m7G) is one