There is experimental evidence for a cardiovascular effect of parathyroid hormone (PTH). A rapid positive inotropic and chronotropic action of PTH has been described in different animal species in both in vivo and in vitro conditions (Lhoste et al., 1980; Bogin et al., 1981; Hashimoto et al...
As a result of bone remodelling, calcium ions are released into the central BM cavity6. Consistently, the calcium concentration in the BMM of Col1-caPPR mice, characterised by osteoblastic cell-specific constitutive activation of the receptor for parathyroid hormone (PTH) and PTH-related peptide (...
Low-dose intravenous calcitriol treatment of secondary hyperparathyroidism in hemodialysis patients. Italian Group for the Study of Intravenous Calcitriol. Intravenous calcitriol is known to directly suppress PTH secretion and release. We evaluated the effect of four months of treatment with low-dose in...
Parathyroid Hormone (PTH) plays a crucial role in the maintenance of calcium homeostasis directly acting on bone and kidneys and indirectly on the intestine. However, a large family of PTH-related peptides exists that exerts other physiological effects on different tissues and organs, such as the...
Here we investigate the specific role of Klotho expressed in the parathyroid glands (PTGs) in mediating parathyroid hormone (PTH) and serum calcium homeostasis, as well as the potential interaction between calcium-sensing receptor (CaSR) and Klotho. We generated mouse strains with PTG-specific ...
Bone mainly functions as a supportive framework for the whole body and is the major regulator of calcium homeostasis and hematopoietic function. Recently, an increasing number of studies have characterized the significance of bone as an endocrine organ, suggesting that bone-derived factors regulate loca...
Other factors that theoretically could contribute to ALDO production and raise PAC (for example, ACTH, catecholamines and PTH as seen in Figure 1) are irrelevant as the minipump provides an autonomous and continuous source of ALDO release with persistent elevations in PAC. Thus, ALDOST rats, ...
Thus, the simultaneous role of factors such as dosing, control of serum calcium and phosphorus, and demographic variables such as age, sex, race, and duration of ESRD is not well understood. We examined the relationship between the administration of calcitriol and PTH suppression in a cohort of...
Cell proliferation and PTH secretion in the parathyroid gland are known to be regulated by vitamin D and extracellular calcium. Here, we examined the vitam... K Weber,U Zeitz,C Bergow,... - 《Journal of Bone & Mineral Research the Official Journal of the American Society for Bone & Miner...
BACKGROUND: Octreotide has been shown to lower urinary calcium in primary hyperparathyroidism although the mechanism remains unclear. This study examined the effect of octreotide on parathyroid hormone (PTH) secretion from human parathyroid cells in culture and as isolated cells. Additionally in situ hyb...