In recent years, a growing body of evidence has alluded to a central role in replisome regulation for the ubiquitin-dependent protein segregase p97, also known as valosin-containing protein (VCP) in metazoans an
Therefore, timely repair of TOP2-DNA complexes is crucial for the maintenance of genome stability. TOP2 is a large protein, and it is well understood that, in the presence of TOP2 poisons, TOP2-mediated DSB remains concealed within the TOP2-DNA complex until processing of the TOP2 adduct...
Mutations in the PEX1 gene, which encodes a protein required for peroxisome biogenesis, are the most common cause of the Zellweger spectrum diseases. The recognition that Pex1p shares a conserved ATP-binding domain with p97 and NSF led to the discovery of the extended family of AAA+-type AT...
At the mito- chondrial interface, Ubx2 binds to stalled precursors at the TOM complex, recruiting Cdc48 (human homolog p97/VCP) and its cofactors Ufd1-Npl4 (human homolog UFD1 and NPLOC4) via its UBX domain, facilitat- ing their proteasomal degradation. Recent research has unveiled a ...
Cell growth and proliferation are two diverse processes yet always linked. Akt1, a serine/threonine kinase, is a multi-functional protein implicated in regulation of cell growth, survival and proliferation. Though it has a role in G1/S progression, the m
Nipah virus (NiV) is a highly pathogenic paramyxovirus that causes lethal encephalitis in humans. We previously reported that the V protein, one of the three accessory proteins encoded by the P gene, is one of the key determinants of the pathogenesis of
doi:10.1007/S00412-016-0587-4Kristijan RamadanSwagata HalderKatherine WisemanBruno VazSpringer Berlin HeidelbergK. Ramadan, et al., Strategic role of the ubiquitin-dependent segregase p97 (VCP or Cdc48) in DNA replication, Chromosoma 126 (1) (2017) 17-32....
genome instability that in turn causes tumorigenesis. Recent TCGA study has further revealed the connection between mutations in alteration of DUBs and various types of tumors. In addition, emerging drug design based on DUBs provides a new avenue for anti-cancer therapy. In this review, we will ...
Viral protein U (Vpu) is a type 1 membrane-associated accessory protein that is unique to human immunodeficiency virus type 1 (HIV-1) and a subset of related simian immunodeficiency virus (SIV). The Vpu protein encoded by HIV-1 is associated with two pri
Similarly, mitochondria co-aggregated with TDP-43 in heterozygous knock-in mice bearing an ALS-associated R155H mutation in valosin-containing protein (VCP; also called p97, cdc48 in yeast – further referred to as VCP/p97) [34], [35]. Direct evidence that disruption of mitochondrial ...